PDQ (Physician Data Query)

Extract

PDQ (Physician Data Query)is the National Cancer Institute’s source of comprehensive cancer information. It contains peer-reviewed, evidence-based cancer information summaries on treatment, supportive care, screening, prevention, genetics, and complementary and alternative medicine. The summaries are regularly updated by six editorial boards. The following PDQ summaries were recently updated:

Win AK, Young JP, Lindor NM, et al.: Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study. J Clin Oncol 30 (9): 958–64, 2012. PMID: 22331944

Win AK, Lindor NM, Young JP, et al.: Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome. J Natl Cancer Inst 104 (18): 1363–72, 2012. PMID: 22933731

The PDQ Genetics of Colorectal Cancer summary and the PDQ Genetics of Breast and Ovarian Cancer summary were recently updated to include information about the risk of female breast cancer in Lynch syndrome. Retrospective studies have been inconsistent, but the largest prospective study to date of 446 unaffected mismatch repair gene mutation carriers who were followed for 10 years found an elevated risk of breast cancer, with a standardized incidence ratio (SIR) of 3.95 (95% confidence interval [CI], 1.59–8.13; P =.001). Another analysis of 764 mismatch repair gene mutation carriers who had a prior diagnosis of colorectal cancer found a 10-year risk of breast cancer following colorectal cancer of 2% (95% CI, 1%–4%), with a SIR of 1.76 (95% CI, 1.07–2.59). To review the summaries, please use the following links: http://www.cancer.gov/cancertopics/pdq/genetics/colorectal/HealthProfessional/Page4#Section_120http://www.cancer.gov/cancertopics/pdq/genetics/breast-and-ovarian/healthprofessional/allpages#Section_2273