Researchers from Italy recently discovered an aggressive subtype of stage I adenocarcinoma of the lung, with molecular characteristics similar to those found in advanced lung cancer. The group identified and validated the 10-gene high-risk prognostic signature in 507 patients by analyzing gene expression, somatic mutations, methylation, copy number variations, and proteomic information. They verified the panel in 468 patients from the Cancer Genome Atlas. The high-risk patients had a fourfold-higher risk of death and a 3-year overall survival rate of 84.2%, compared with 95.6% for low-risk patients.

“Although 60% of stage I lung cancer patients are cured by surgery, a relatively high percentage of patients, almost 40%, relapse within 5 years,” said Pier Paolo Di Fiore, M.D., director of the Molecular Carcinogenesis and Stem Cell Biology Research Unit at the European Institute of...

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