The Deoxyribonucleic Acid (DNA) Content of Sternberg-Reed Cells of Hodgkin's Disease

Abstract

The DNA content of Sternberg-Reed cells of Hodgkin's disease was determined by Feulgen cytophotometry. An increased DNA content per cell nucleus above the diploid (2n) level was found which corresponded to the nuclear size and degree of nuclear lobulation. The findings were considered as evidence in support of the concept that the Sternberg-Reed nuclei undergo endomitosis and polyploidization during their development from the reticulum cells.