Chromosome Analysis of Three Virus-Associated Chicken Tumors: Rous Sarcoma, Erythroleukemia, and RPL12 Lymphoid Tumor

Summary

A qualitative and quantitative chromosome analysis of normal chicken cells, Rous sarcoma cells, erythroleukemia cells, and RPL12 lymphoid tumor cells was carried out. The mode of the counts for normal chicken cells was 78. Rous sarcoma cells and erythroleukemia cells were essentially diploid with no visible aberrations. One chicken had an unusual Rous sarcoma with hyperdiploid cells. The homotransplantable RPL12 lymphoid tumor cells were hyperdiploid with counts from 80 to 84. The hyperdiploidy involved an increased number of chromosomes (“microchromosomes”) smaller than #13; the larger, identifiable chromosome pairs showed no departure from the norm.