A Transplantable Granular Cell Myoblastoma in Strain C3H Mice

Summary

Neoplasms having the histologic features of granular cell myoblastomas in man were found in the uterine cervix of estrogen-treated mice. One of these was successfully transplanted and is now in the fourth generation. The transplants grow slowly, and only a small percentage were successfully transplanted in the early generations. In the second generation, 16 months after transfer, one mouse had a tumor 2 cm in diameter that was composed of both granular cell myoblastoma tissue and areas of malignant fibroblasts. Another mouse, 20 months after transfer from the same tumor, had a nodule in the right flank, with the gross features of a granular cell myoblastoma, and a second discrete nodule in the left flank, diagnosed as a fibrosarcoma. The possible relationship between the two types of malignant tissue is discussed, and the transplantation history and histologic descriptions of the tumors are given.