Studies on Reovirus. III. A Labile, Single-Stranded Ribonucleic Acid Associated With the Late Stages of Infection

Summary

A labile ribonucleic acid (RNA) that stains red with acridine orange has been located in the cytoplasm of monkey kidney cells during the late stages of the infectious cycle with reovirus. This RNA is distinct from the double-stranded “Veen staining” RNA forming the core of the mature virion. Apparently this is a single-stranded, extremely labile RNA, associated with reovirus-infected monkey kidney cells late in the Infectious cycle. At this time large amounts of antigenic reovirus protein can be detected readily by staining with fluorescent antibody.