Contribution of Antiviral Immunity to Oncolysis by Newcastle Disease Virus in a Murine Lymphoma

Summary

By the injection of small numbers of cells with a large excess of Newcastle disease virus (NOV), an oncolytic effect was demonstrated against an ascites lymphoma induced by the Gross virus. Inbred histocompatible C3H mice were used in several experiments. Preimmunization of mice with NDV increased the oncolytic effect of that virus. With influenza virus an irregular oncolytic effect-occurred, but preimmunization with influenza virus did not increase resistance to ascites lymphoma cells treated with NDV. Syngeneic mice survived repeated injections of large numbers of NDV-treated leukemic spleen cells, but immunization with such cells did not confer significant resistance to challenge with smaller numbers of leukemic cells injected without virus.