Immunofluorescent Studies of Mouse and Hamster Cell Surface Antigens Induced by Polyoma Virus

Summary

The surface antigens of mouse and hamster polyoma-induced tumor cells and of mouse cells in the lytic cycle of polyoma virus infection were studied with the indirect fluorescent-antibody technique. Sera of mice immunized with polyoma virus or polyoma tumor cells were examined. Reactions were observed between the various sera and polyoma-transformed mouse and hamster cells or mouse cells in the lytic cycle. No reaction was noted with normal mouse embryo cells, simian virus 40-transformed mouse or hamster cells, or with mouse cells infected with herpesvirus. In addition, control sera from mice immunized with simian virus 40, a methylcholanthrene-induced tumor, or a mammary tumor failed to react with the polyoma-transformed cells.