Vascular Abnormalities Induced by Benzo[a]pyrene: An In Vivo Study in the Hamster Cheek Pouch

Summary

The vascular changes in the pouch of the hamster during application of benzo[a]pyrene were studied in vivo. There appears to be a relationship between the development of the vascular changes and histologic progress of dysplastic epithelial lesions. Benign epithelial hyperplasia is characterized by hyperemia, massive dilatation, tortuosity of large veins, and diffuse capillary neovascularization. Striking vascular alterations, such as fusiform venous and arterial abnormalities and extensive neovascularization, were regularly associated with malignant epithelial lesions. The development of benzo[a]pyrene-induced cheek-pouch carcinoma is paralleled and preceded by significant vascular stromal changes.