Chromosomal Alteration and Development of Tumors. XIX. Chromosome Constitution of Tumor Cells in 16 Plasma Cell Neoplasms of BALB/c Mice

Summary

Karyotypes of 16 plasma cell neoplasms induced by mineral oil or mineral oil adjuvants in BALB/c mice were |analyzed. Of these neoplasms, 13 produced specific immunoglobulins, 13 had stemlines characterized by hypotetraploid chromosome numbers, 1 (MOPC-31C) had a hyperdiploid stemline, 1 (MOPC-70E), a hypotriploid stemline, and 1 (Adj PC-6C), a hypertetraploid stemline. The stemline cells of 13 neoplasms had 1–4 marker chromosomes, whereas those of 3 neoplasms (MOPC31B, MOPC-70A, and MOPC-70E) had no detectable marker chromosomes. The wide range of chromosome numbers usually found in the early transplant generations narrowed in the later transplant generations. Three neoplasms not producing specific γ-immunogIobulins evolved from 3 neoplasms characterized by the production of γA serum, lambda chain and γF serum, and excess kappa, respectively. The karyotypes of these negative neoplasms differed significantly from those of the parental positive neoplasms.