Studies on Inhibition of Viral Oncogenesis. I. Reduced Tumor Incidence in Hamsters Inoculated With Adenovirus 12 and Treated With Clam Extracts

Summary

Newborn hamsters were inoculated subcutaneously with adenovirus type 12, and 4–5 days later they were treated with a series of subcutaneous injections of extracts made from the shucked whole body of the hard clam, Mercenaria mercenaria, or from its liver (digestive diverticulum). Incidence of subsequent formation of solid subcutaneous tumors was then reduced from 71, 46, and 87% in the control hamsters to 24, 4, and 32% in the treated animals. This study extended the observations by other workers and us on the inhibition of oncogenesis due to adenovirus 12 in hamsters.