Systemic Transfer of Tumor Immunity: Delayed Hypersensitivity and Suppression of Tumor Growth

Summary

Delayed hypersensitivity and tumor-specific growth suppression were passively transferred to unimmunized recipient strain-2 guinea pigs. Transfer was accomplished by the injection of peritoneal exudate cells into the heart of unimmunized strain-2 animals. The recipients were challenged by the intradermal inoculation of living tumor cells; tumorspecific delayed hypersensitivity and growth suppression were obtained. Cell fractions containing lymphocytes and neutrophils were the most active in the passive transfer of tumor-specific delayed hypersensitivity and tumor growth suppression.