Appearance of Collagen Proline Hydroxylase in Sera of Mice With Implanted Sarcomas

Summary

A number of solid tumors were shown to have relatively high contents of collagen proline hydroxylase, one of the enzymes involved in collagen biosynthesis. Tumor tissue from three mouse sarcomas—fibrosarcoma SaD2, rhabdomyosarcoma BW10139, and chondrosarcoma DC II—attained high enzyme levels. Coincident with the increase in the activity of collagen proline hydroxylase in the tumors, the enzyme increased in the serum of the host animals. Should suitable methods be developed, appearance in the serum of this normally intracellular enzyme may prove useful in the diagnosis of certain collagen-forming tumors and other collagen disorders in man.