Relation Between Neutralization of Epstein-Barr Virus and Antibodies to Cell-Membrane Antigens Induced by the Virus

Pearson, Gary; Dewey, Faye; Klein, George; Henle, Gertrude; Henle, Werner

doi:10.1093/jnci/45.5.989

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Relation Between Neutralization of Epstein-Barr Virus and Antibodies to Cell-Membrane Antigens Induced by the Virus

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Summary

The neutralization of Epstein-Barr virus (EBV) infectivity by sera with known antibody activities against EBV-associated antigens was investigated in experimentally infected Raji and RPMI 64-10 cells. Antibodies against EBV-induced cell-membrane antigens were apparently responsible for neutralization of viral infectivity. Antibodies against EBV capsid antigens and EBV-induced early antigens were not involved. The implication of these results on the relationship of the membrane antigens to the infectious virus particle is discussed.

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Relation Between Neutralization of Epstein-Barr Virus and Antibodies to Cell-Membrane Antigens Induced by the Virus

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Relation Between Neutralization of Epstein-Barr Virus and Antibodies to Cell-Membrane Antigens Induced by the Virus

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