Serum Group-Specific (Gc) Protein Concentrations in Patients With Carcinoma, Melanoma, Sarcoma, and Cancers of Hemato-poietic Tissues as Determined by Radial Immunodiffusion

Summary

The concentration of the group-specific (Gc) protein was determined by radial immunodiffusion in 1,238 sera from patients with different types of cancer and 256 sera from healthy controls. The mean Gc protein concentrations were significantly higher for females than for males in both the healthy controls and cancer patients. For both controls and cancer patients, significant differences in mean Gc protein concentration were found between sera of different Gc groups, the highest levels being found in group Gc 1:1 sera and the lowest in Gc 2:2 sera. The mean Gc protein concentration was significantly higher than normal in male patients with cancers of lymphatic tissue other than lymphatic leukemia, whereas the Gc protein concentration in patients with all other types of cancer did not differ significantly from normal.