Cross-Reacting Tumor-Specific Transplantation Antigens in Methylcholanthrene-Induced Guinea Pig Sarcomas

Holmes, E. C.; Morton, D. L.; Schidlovsky, G.; Trahan, E.

doi:10.1093/jnci/46.4.693

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Cross-Reacting Tumor-Specific Transplantation Antigens in Methylcholanthrene-Induced Guinea Pig Sarcomas

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Summary

Cross-reacting tumor-specific transplantation antigens were demonstrated in two of three methylcholanthrene-induced strain-2 guinea pig sarcomas. In addition, water-soluble extracts prepared from the two cross-reacting tumors contained cross-reacting tumor-specific transplantation antigens. Electron microscopic studies revealed virus-like particles similar to those previously described in strain-2 guinea pig leukemias in two of the three tumors examined, but the cross reactions between these tumors could not be correlated with the presence of these viral particles.

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Cross-Reacting Tumor-Specific Transplantation Antigens in Methylcholanthrene-Induced Guinea Pig Sarcomas

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Cross-Reacting Tumor-Specific Transplantation Antigens in Methylcholanthrene-Induced Guinea Pig Sarcomas

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