Alteration of Skin in Gross Leukemia. II. Kinetic, Preleukemic, and Irradiation Studies

Summary

The validity of the heterogenization hypothesis and the role of virus in syngeneic skin-graft rejection were examined. Correlative analyses of the time of development of heterogenization, the time of appearance of tumor cells in normal tissues, and the influence of X irradiation on the rejection process were conducted. Gross passage A virus and C3H/Bi and (C3H/Bi × DBA/2)F₁ inbred strains of mice were used. During the kinetic, preleukemic, and irradiation studies, it was found that the tumor cell itself is a major factor in the rejection phenomenon. The function of virus in graft rejection and the virus-related explanatory hypothesis of antigenic alteration should be reexamined.