Transfer RNA Species in Solid Human Tumors

Summary

Transfer RNA populations isolated from a variety of solid human tumors were compared to transfer RNAs from normal tissues by methylated albumin Kieselguhr (MAK) and reverse phase chromatography. Most tumors examined contained transfer RNA species chromatographically indistinguishable from those found in normal human tissues. However, 1 of 3 breast carcinomas contained tyrosyl transfer RNA which eluted from MAK and reverse phase columns at a higher salt concentration than the bulk of the corresponding RNA from normal tissues. This tyrosyl transfer RNA was chromatographically similar to that found in many cultured tumor cells.