Transplantation of a Human Mammary Carcinoma Cell Line (BT 20) Into Nude Mice

Ozzello, L.; Sordat, B.; Merenda, C.; Carrel, S.; Hurlimann, J.; Mach, J. P.

doi:10.1093/jnci/52.5.1669

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Transplantation of a Human Mammary Carcinoma Cell Line (BT 20) Into Nude Mice

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Summary

Cell suspensions of a human mammary carcinoma cell line (BT 20), when injected subcutaneously into nude athymic mice (BALB/c Nu/Nu), produced tumor nodules at the injection site. Subsequent serial transplantations also gave rise to neoplastic nodules after latency periods averaging 3 weeks. The nodules displayed morphologic and functional characteristics comparable to those of the original tumor cells. Metastases, however, were not observed in any of the tumor-bearing mice.

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Transplantation of a Human Mammary Carcinoma Cell Line (BT 20) Into Nude Mice

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