Effect of Beta-Oxidized Nitrosamines on Syrian Golden Hamsters. II. 2-Oxopropyl-n-propylnitrosamine

Summary

2-Oxopropyl-n-propylnitrosamine (2-OPPN), a metabolite of di-n-propylnitrosamine (DPN) due to β,n-oxidation, was carcinogenic in the Syrian golden hamster. The main target organ of 2-OPPN was the respiratory tract, particularly the nasal cavity and the trachea. In the trachea, the upper segment was the predilected site of tumor development (papillary polyps). In addition to the neoplasms in the respiratory system, numerous tumors were found in the liver and kidlleys. The biologic effect of 2-OPPN was compared with that of 2-hydroxypropyl-npropy1nitrosamine and methyl-n-propylnitrosamine, other metabolites of DPN by β-oxidation.