Brief Communication: Synergistic Effects of Benzo[alpyrene and Diethylnitrosamine on Respiratory Carcinogenesis in Hamsters

Montesano, Ruggero; Saffiotti, Umberto; Ferrero, Alessandro; Kaufman, David G.

doi:10.1093/jnci/53.5.1395

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Brief Communication: Synergistic Effects of Benzo[alpyrene and Diethylnitrosamine on Respiratory Carcinogenesis in Hamsters

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Summary

Combined treatment of hamsters with a loweffect dose schedule of benzo[a]pyrene plus ferric oxide given intratracheally, followed by a low dose of diethylnitrosamine given systemically, resulted in a synergistic tumor response. Squamous cell carcinomas of the tracheobronchial tract were observed only in the group receiving combined treatment; administration of single carcinogens did not cause similar tumors.

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Brief Communication: Synergistic Effects of Benzo[alpyrene and Diethylnitrosamine on Respiratory Carcinogenesis in Hamsters

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Brief Communication: Synergistic Effects of Benzo[alpyrene and Diethylnitrosamine on Respiratory Carcinogenesis in Hamsters

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