Brief Communication: Matrical Inclusions Induced by Clofibrate in Hepatic Microbodies of Rats Fed 2-Acetylaminofluorene

Tsukada, Hideyuki; Mochizuki, Yohichi; Gotoh, Mikio

doi:10.1093/jnci/54.2.519

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Brief Communication: Matrical Inclusions Induced by Clofibrate in Hepatic Microbodies of Rats Fed 2-Acetylaminofluorene

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Summary

Abnormal inclusions in microbodies were induced by clofibrate in hepatocytes of hyperplastic liver nodules in rats fed 2-acetylaminofluorene. These were matrical tubules and plates, each with the same ultrastructural features as those reported previously by other investigators. A hyperplastic state of hepatocytes induced by hepatocarcinogens might be related to the formation of these inclusions in response to clofibrate.

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Brief Communication: Matrical Inclusions Induced by Clofibrate in Hepatic Microbodies of Rats Fed 2-Acetylaminofluorene

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Brief Communication: Matrical Inclusions Induced by Clofibrate in Hepatic Microbodies of Rats Fed 2-Acetylaminofluorene

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