Brief Communication: Desmosterol in Rat Central and Peripheral Nervous Systems During Normal and Neoplastic Growth

Summary

Intrarectal administration of 0.5 ml of a 0.25% RESULTS solution of N-methyl-N-nitrosourea twice weekly for 42 weeks to female inbred strain-2 guinea pigs induced large-bowel adenocarcinomas in 9 of 10 animals in 38–56 weeks. Controls did not show cancer. The lesions were infiltrative or constrictive, which distinguished them from chemically induced large-bowel cancers of rats and mice.