Brief Communication: Moloney Sarcoma Virus-Induced Tumors in Athymic (Nude) Mice: Growth Pattern and Antibody Responses

Davis, Stephen

doi:10.1093/jnci/54.3.793

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Brief Communication: Moloney Sarcoma Virus-Induced Tumors in Athymic (Nude) Mice: Growth Pattern and Antibody Responses

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Summary

Tumor growth and antibody production were evaluated in nude (nu/nu) mice and their heterozygous normal (+/nu) littermates after inoculation of Moloney sarcoma virus (MSY). Sarcoma-bearing nude mice developed progressively growing tumors, whereas 53% of their normal counterparts showed tumor regressions. By indirect membrane fluorescence, significant amounts of IgG antibody to MSY could be detected in thymus-bearing but not in nude mice.

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Brief Communication: Moloney Sarcoma Virus-Induced Tumors in Athymic (Nude) Mice: Growth Pattern and Antibody Responses

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Brief Communication: Moloney Sarcoma Virus-Induced Tumors in Athymic (Nude) Mice: Growth Pattern and Antibody Responses

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