Brief Communication: Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity

Rosenoff, Stephen H.; Olson, Harry M.; Young, David M.; Bostick, Frieda; Young, Robert C.

doi:10.1093/jnci/55.1.191

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Brief Communication: Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity

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Abstract

After one dose of adriamycin, a subacute cardiomyopathy was observed in the mouse by both light and electron microscopy. The microscopic alterations were characterized by single-cell necrosis and mitochondrial degeneration. These lesions were simitar to those seen in man and shortly preceded fatal toxicity.

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Brief Communication: Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity

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Brief Communication: Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity

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