Specific Carcinogenic Effect of N-Methyl-N-nitrosourea on the Midventral Sebaceous Gland of the Gerbil (Meriones unguiculatus)

Haas, Hermann; Hilfrich, Jörn; Kmoch, Norbert; Mohr, Ulrich

doi:10.1093/jnci/55.3.637

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Specific Carcinogenic Effect of N-Methyl-N-nitrosourea on the Midventral Sebaceous Gland of the Gerbil (Meriones unguiculatus)

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Summary

Gerbils (Meriones unguiculatus), given N-methyl-N-nitrosourea iv once weekly for 15 weeks at doses related to the mean lethal dose, developed tumors of the species-specific midventral sebaceous gland. These neoplasms were more frequent in males than females and were histologically classified as sebaceous adenomas or carcinomas of varying differentiation.

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Specific Carcinogenic Effect of N-Methyl-N-nitrosourea on the Midventral Sebaceous Gland of the Gerbil (Meriones unguiculatus)

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Specific Carcinogenic Effect of N-Methyl-N-nitrosourea on the Midventral Sebaceous Gland of the Gerbil (Meriones unguiculatus)

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