Local Antitumor Activity of a Primary and an Anamnestic Response to a Syngeneic Guinea Pig Hepatoma

Abstract

After intradermal (id) injection, the line-IO hepatoma grew progressively in nonimmune guinea pigs, whereas the line-l hepatoma grew for approximately 2 weeks, developed central necrosis, ulcerated, and regressed. Growth of the line-IO hepatoma was suppressed when line-IO hepatoma cells were mixed with antigenically distinct line-l hepatoma cells before id injection into syngeneic strain-2 guinea pigs. Mixture of line-IO with irradiated line-lor viable strain-2 embryo cells did not inhibit tumor growth. Preimmunization of recipients to line-l cells abrogated the suppression of tumor growth from mixtures of line-1 and line-10.