Factor Suppressing Alphal Fetoprotein Production

Svet-Moldavsky, George J.; Tumyan, Bella G.; Karmanova, Natalia V.; Belianchikova, Natalia I.

doi:10.1093/jnci/55.5.1075

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Factor Suppressing Alphal Fetoprotein Production

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Summary

The injection of sera of adult mice or of a 20% extract of small and large intestine, liver, kidney, spleen, thymus, and lungs of adult mice suppressed the alpha_l fetoprotein production in syngeneic newborn recipients. Extracts of the striated muscles of adult mice had a meager inhibitory effect. Extracts of mouse embryonic intestine and those of the whole embryo without the gastrointestinal tract had almost negligible amounts of suppressing factor. The possible role of humoral factors regulating the synthesis of embryonic antigens for the control of tumor growth was discussed.

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