Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats

Reddy, Bandaru S.; Narasawa, T.; Weisburger, J.H.; Wynder, E.L.

doi:10.1093/jnci/56.2.441

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Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats

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Summary

The promoting effect of sodium deoxycholate (DC) on colon carcinogenesis was studied in female F344 germfree rats. Animals received intrarectaI (ir) instillations of N-methyl-N′- nitro-N-nitrosoguanidine (MNNG) for 4 weeks (total dose, 16 mg/rat), then weekly ir doses of DC (total dose, 3 g/rat); the rats were autopsied 52 weeks after the first injection. DC increased the number ofMNNG-induced colon adenocarcinomas. No tumors were in the colons of germfree rats given DC alone. It was concluded that DC (present in high concentrations in human stools) had a promoting effect on colon carcinogenesis in rats.

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Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats

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Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats

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