Allogeneic Tumor-Syngeneic Muscle Sandwich Grafts: A Method for Promoting Nonspecific Growth

Summary

In H-2-incompatible mice, four strain-specific transplantable murine tumors grew when sandwiched between layers of muscle syngeneic to the intended recipient. The allogeneic tumor-syngeneic muscle sandwich (TMS) graft did not grow in recipients presensitized to the allogeneic tumor and in recipients immunized concurrently with tumor or skin allografts from the same strain as the sandwiched tumor. Third-party muscle, allogeneic to both tumor and host, also was effective in promoting nonspecific growth. The escape of the allogeneic tumor from immunologic destruction when it was implanted as a TMS graft may have been due to an afferent blockade.