Adenocarcinoma of the Glandular Stomach Following 3-Methylcholanthrene, N-Nitrosodiethylamine, or N-Nitrosodimethylamine Feeding in Carcinogen-Susceptible Inbred Syrian Hamsters

Abstract

Invasive adenocarcinoma of the glandular stomach was induced in 3 BIO® 87.20 inbred Syrian hamsters by the administration of 1 ppm N-nitrosodiethylamine or N-nitrosodimethylamine in the drinking water, and in 2 BIO® 15.16 and 5 BIO® 72.29 inbred Syrian hamsters by gavage of 3-methylcholanthrene. In contrast, many other similarly treated inbred Syrian hamster lines did not develop carcinoma of the glandular stomach. The glandular stomachs of rats and mice are resistant to polycyclic hydrocarbon carcinogenesis; however, the glandular stomachs of certain inbred Syrian hamsters develop adenocarcinoma after polycyclic hydrocarbon gavage. This work demonstrated the importance of genetic factors.