Afferent and Efferent Interference of Cell-Mediated Cytotoxic Reactions by Heparin

Abstract

Heparin influenced the induction (afferent interference) and effector (efferent interference) phases of cell-mediated cytotoxic reactions against FBL-3 cells, a syngeneic Friend virus-induced leukemia in inbred C57BL/6 mice. Heparin was cytotoxic at high concentrations (≥100 U/ml) and inhibitory for cell-mediated cytotoxic response at lower concentrations (≤50 U/ml).