Carcinogenicity Test of Two Unsaturated Derivatives of N-Nitrosopiperidine in Sprague-Dawley Rats

Abstract

Two unsaturated derivatives of N-nitrosopiperidine (NP), N-nitroso-1,2,3,6-tetrahydropyridine (NTP) and N-nitrosoguvacoline (NGC), were administered to Sprague-Dawley rats as solutions in drinking water at concentrations equimolar (0.88×10⁻³M) with those used to test NP. NTP gave rise to hepatocellular tumors in contrast to the esophageal or olfactory tumors that were induced by NP. NGC did not induce tumors under these test conditions.