A Carcinogenicity Assay of Mirex in Charles River CD Rats

Ulland, Borge M.; Page, Norbert P.; Squire, Robert A.; Weisburger, Elizabeth K.; Cypher, Robert L.

doi:10.1093/jnci/58.1.133

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A Carcinogenicity Assay of Mirex in Charles River CD Rats

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Abstract

The long-term administration of 50 and 100 ppm of Mirex in the diets of male and female Charles River CD rats was associated with a spectrum of liver lesions, from foci or areas of cellular alteration and neoplastic nodules to hepatocellular carcinoma. Statistically significant numbers of neoplastic nodules were observed in the livers of male rats receiving the high dose. Neoplastic nodules and hepatocellular carcinomas were not observed in control rats.

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A Carcinogenicity Assay of Mirex in Charles River CD Rats

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A Carcinogenicity Assay of Mirex in Charles River CD Rats

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