Foreign-Body Tumors of Mice: Strain and Sex Differences in Latency and Incidence

Abstract

Sarcomas were induced by sc implantation of unplasticized polyvinylchloride acetate films in female and male mice of strains AKR/J, BALB/cJ, BALB/cWat, CBA/H and CBA/HT6, C3H/HeJ, C57BL/10ScSn, C57BL/6J-bg^J, C57BR/cdJ, DBA/1J, 1/LnJ, LP/J, SJL/J, X/Gf, 129/J, and hybrids (CBA/H-T6 × AKR/J)F₁, (C57BL/10ScSn × CBA/H or CBA/H-T6)F₁ (C57BL/6Jbg^J × C57BL/6J)F¹. The strains and sexes showed marked differences in incidence and mean latency of resulting tumors. Crucial information was provided for the selection of appropriate mouse strains for the study of interrelationships between genotypes, defined somatic properties, and the multifactorial process of foreign-body tumorigenesis.