Effect of Intestinal Microflora Suppression on Liver Carcinogenicity of Dimethylnitrosamine in Syrian Hamsters: Brief Communication

Love, Lori A.; Pelfrene, Alain; Garcia, Humberto

doi:10.1093/jnci/58.6.1835

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Effect of Intestinal Microflora Suppression on Liver Carcinogenicity of Dimethylnitrosamine in Syrian Hamsters: Brief Communication

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Abstract

Liver tumors induced by dimethylnitrosamine showed an increased incidence in Syrian hamsters with intestinal microflora suppressed by antibiotics, as compared with the incidence in animals not treated with antibiotics. The possible mechanisms, including metabolic alterations caused by changes in the normal microflora population, were discussed.

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Effect of Intestinal Microflora Suppression on Liver Carcinogenicity of Dimethylnitrosamine in Syrian Hamsters: Brief Communication

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Effect of Intestinal Microflora Suppression on Liver Carcinogenicity of Dimethylnitrosamine in Syrian Hamsters: Brief Communication

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