Simplified Radioimmunoassay for Viral Antigens: Use of Staphylococcus aureus as an Adsorbent for Antigen—Antibody Complexes: Brief Communication

Abstract

In a rapid method for the radioimmunoassay (RIA) of viral antigens, Staphylococcus aureus was used as the adsorbent for antigen-antibody complexes (“protein A” molecules on the cell walls of certain strains of staphylococci have a strong affinity toward lgG molecules). The results showed that this method could be used instead of the double-antibody technique, with the same or probably higher sensitivity in precipitation as well as competition RIA's.