Construction of a DBA/2.Fv-2r Congenic Strain. Apparent Lethality of the Homozygous Fv-2r Genotype: Brief Communication

Blank, Kenneth J.; Lilly, Frank

doi:10.1093/jnci/59.4.1335

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Construction of a DBA/2.Fv-2^r Congenic Strain. Apparent Lethality of the Homozygous Fv-2^r Genotype: Brief Communication

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Abstract

From the (C57BL/6 × DBA/2)F₁ cross, 13 serial backcrosses to the DBA/2 parental mouse strain were bred with selection by progeny testing in each generation for the Fv-2^s/Fv-2^r heterozygous genotype. Intercrossing heterozygotes of the 13th backcross generation produced no Fv-2^r/Fv-2^r homozygotes. Homozygosity for the Fv-2^r allele thus appeared to be lethal on a DBA/2 background and in the absence of protector gene(s) of the C57BL strain.

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Construction of a DBA/2.Fv-2^r Congenic Strain. Apparent Lethality of the Homozygous Fv-2^r Genotype: Brief Communication

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Construction of a DBA/2.Fv-2r Congenic Strain. Apparent Lethality of the Homozygous Fv-2 r Genotype: Brief Communication

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Construction of a DBA/2.Fv-2^r Congenic Strain. Apparent Lethality of the Homozygous Fv-2^r Genotype: Brief Communication