Effects of Gonadectomy on Foreign-Body Tumorigenesis in CBA/H Mice

Abstract

Sarcomas were induced by sc implantation of unplasticized polyvinylchloride-vinylacetate films in gonadectomized and normal male and female CBA/H mice. Gonadectomy did not demonstrably Influence tumor incidence and tumor latencies in males but significantly prolonged tumor latencies in females. The results suggest that estrogen influences the pace of foreign-body tumorigenesis in CBA/H mice.