Friend Murine Leukemia Virus Resistance in Japanese Wild Mice: Possible Allelism With Fv-4 in FRG Mice

Suzuki, S.; Tsuji, K.; Moriwaki, K.

doi:10.1093/jnci/66.4.729

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Friend Murine Leukemia Virus Resistance in Japanese Wild Mice: Possible Allelism With Fv-4 in FRG Mice

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Abstract

A dominant gene (R^m ) for resistance to ecotropic murine leukemia virus was found in Japanese wild mice (Mn) and was similar to the FV-4^r gene in inbred FRG mice. About one fourth of the progeny of the cross (BALB/c × Mn) × (FRG × BALB/c) produced only resistant progeny when crossed to BALB/c mice, which indicated that Rm and Fv-4 are at the same chromosomal location. This evidence for allelism was confirmed by the finding that matings of BALB/c mice partially congenic for R^m or for Fv-4 yielded progeny that produced only resistant offspring when crossed to BALB/c mice.

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Friend Murine Leukemia Virus Resistance in Japanese Wild Mice: Possible Allelism With Fv-4 in FRG Mice

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Friend Murine Leukemia Virus Resistance in Japanese Wild Mice: Possible Allelism With Fv-4 in FRG Mice

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