Retinoic Acid: Enhancement of a Tumor and Inhibition of Interferon's Antitumor Action

Baron, Samuel; Kleyn, Kathryn M.; Russell, Jeffry K.; Blalock, J. Edwin

doi:10.1093/jnci/67.1.95

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Retinoic Acid: Enhancement of a Tumor and Inhibition of Interferon's Antitumor Action

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Abstract

The effect of trans-retinoic acid on the growth of P388 lymphoid tumors in inbred female DBA/2 mice in the presence or absence of interferon (IFN) treatment was studied. This acid derivative of vitamin A enhanced local tumor growth, trans-Retinoic acid also partially reversed IFN protection against tumor growth and mortality.

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Retinoic Acid: Enhancement of a Tumor and Inhibition of Interferon's Antitumor Action

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Retinoic Acid: Enhancement of a Tumor and Inhibition of Interferon's Antitumor Action

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