Aryl Hydrocarbon (Benzo[a]pyrene) Hydroxylase in Guinea Pig Lymphoid Tissue

Bast, R. C.; Miller, H.; Rapp, H. J.; Gelboin, H. V.

doi:10.1093/jnci/67.2.359

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Aryl Hydrocarbon (Benzo[a]pyrene) Hydroxylase in Guinea Pig Lymphoid Tissue

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Abstract

Aryl hydrocarbon hydroxylase (AHH) activity was detected in a variety of guinea pig lymphoid tissues and was increased by intradermal or ip administration of 3-methylcholanthrene. AHH levels were generally greater in spleen than in lymph node, bone marrow, or thymus. Similar AHH activities were observed in lymphoid tissues from Sewall-Wright inbred strain 2 and strain 13 guinea pigs. Greater AHH activities were associated with peritoneal and alveolar macrophages than with lymph node lymphocytes in the absence of mitogens.

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Aryl Hydrocarbon (Benzo[a]pyrene) Hydroxylase in Guinea Pig Lymphoid Tissue

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Aryl Hydrocarbon (Benzo[a]pyrene) Hydroxylase in Guinea Pig Lymphoid Tissue

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