Re: Urokinase and the Urokinase Receptor: Association With In Vitro Invasiveness of Human Bladder Cancer Cell Lines

Extract

In their May 1997 report, Hudson and McReynolds stated, “To our knowledge, this is the first study demonstrating that bladder tumor cells express the urokinase receptor. . .” (1). I would respectfully point out that expression of the mRNA encoding the urinary plasminogen activator receptor by human transitional carcinoma cell lines and the regulation of it and other plasminogen activator-related proteins (urokinase, tissue plasminogen activator, plasminogen activator inhibitor 1 [PAI-1], and plasminogen activator inhibitor 2 [PAI-2]) by the cytokine-transforming growth factor-b1 and transforming growth factor- a, have been reported previously (2).