Carcinogenic Activity of Analogues of p-Dimethylaminoazobenzene. VII. Effect of Two Methyl Groups in the Pyridine Series23

Summary

This paper completes the series of dimethyl-substituted N,N-dimethyl-4-(4′-[pyridyl-1′-oxide]azo)anilines (J Nat Cancer Inst 37: 365–367, 1966) except for the 3,5-isomer which could not be prepared. The 2′,5′ isomer was the only one of this new group to have strong activity. The remaining isomers have an activity about of the order of p-dimethylaminoazobenzene.

2

Supported by Public Health Service research grant CA 2219 from the National Cancer Institute.

3

Chemical Abstracts' nomenclature: For N,N-dimethyl-1-4-(4′-[2′,5′-dimethylpyridyl-1′-oxide]azo) aniline read 4-[[p-(dimethylamino)phenyl]azo]-2,5-lutidine 1-oxide.

Author notes

4

We wish to thank Dr. George T. Hoffman of St. Vincent's Hospital, New York City, for the microscopic evaluation of the tumors.