The interesting and important paper by Hysmith et al [1] assessing serial immune responses of children after pharyngeal acquisition of Group A streptococci (GAS) is a landmark study. It essentially is a marked extension of the work by Johnson et al [2], which examined the various patterns of serum anti-streptolysin O (ASO) and anti-DNAse B titers after GAS pharyngeal acquisition. The present investigators used almost 200 serial sera collected over a 24-month period from 41 children with 51 new pharyngeal GAS acquisitions to study antibody kinetics and specificity against 13 shared GAS antigens and 18 type-specific M peptides. Most of the antigens used are considered potential GAS vaccine candidates. The results of this impressive effort are both reassuring...

Article PDF first page preview

Article PDF first page preview
Article PDF first page preview
You do not currently have access to this article.