References

1
Steffen
R
Behrens
H.
Traveller's malaria
.
Parasitol Today
 
1992
;
8
(
2
):
61
66
.
2
Jelinek
T
Loscher
T
Nothdurft
HD.
High prevalence of antibodies against circumsporozoite antigen of Plasmodium falciparum without development of symptomatic malaria in travelers returning from sub-Saharan Africa
.
J Infect Dis
 
1996
;
174
(
6
):
1376
1379
.
3
Schlagenhauf
P
Steffen
R
Tschopp
A
, et al.
Behavioral aspects of travelers in their use of malaria presumptive treatment
.
Bull World Health Organ
 
1995
;
73
(
2
):
215
221
.
4
Palmer
KJ
Holliday
SM
Brogden
RN.
Mefloquine, a review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy
.
Drugs
 
1993
;
45
(
3
):
430
475
.
5
Crevoisier
C
Handschin
J
Barré
J
, et al.
Food increases the bioavailability of mefloquine
.
Eur J Clin Pharmacol
 
1997
;
53
:
135
139
.
6
Pennie
RA
Koren
G
Crevoisier
C.
Steady state pharmacokinetics of mefloquine in long-term travellers
.
Trans R Soc Trop Med Hyg
 
1993
;
87
:
459
462
.
7
Gimenez
F
Pennie
RA
Koren
G
Crevoisier
C
, et al.
Stereoselective Pharmacokinetics of mefloquine in healthy Caucasians after multiple doses
.
J Pharm Sci
 
1994
;
83
:
6
:
824
827
.
8
Crevoisier
C
Joseph
I
Fischer
M
Graf
H.
Influence of hemodialysis on plasma concentration-time profiles of mefloquine in two patients with end-stage renal disease: a prophylactic drug monitoring study. Antimicrob Agents Chemother
1995
;
1892
1895
.
9
Weidekamm
E
Rüsing
G
Caplain
H
Sörgel
F
, et al.
Lack of bioequivalence of a generic mefloquine tablet with the standard product
.
Eur J Clin Pharmacol
 
1998
;
54
:
615
619
.
10
Boudreau
E
Schuster
B
Sanchez
J
, et al.
Tolerability of prophylactic Lariam regimens
.
Trop Med Parasit
 
1993
;
44
:
257
265
.
11
Schlagenhauf
P
Lobel
HO
Steffen
R
, et al.
Tolerability of mefloquine in Swissair trainee pilots
.
Am J Trop Med Hyg
 
1997
;
56
:
235
240
.
12
Vuurman
EFPM
Muntjewerff
ND
Uiterwijk
MMC
, et al.
Effects of mefloquine alone and with alcohol on psychomotor and driving performance
.
Eur J Clin Pharmacol
 
1996
;
50
:
475
482
.
13
MacPherson
D
Gamble
K
Tessier
D
, et al. Mefloquine tolerance-randomised, double-blinded, placebo-controlled study using a loading dose of mefloquine in pre-exposed travellers. In: Program and Abstracts of the Fifth International Conference on Travel Medicine; March 24–27, 1997: Geneva, Switzerland. Abstract 220.
14
Steffen
R
Fuchs
E
Schildknecht
J
, et al.
Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting East Africa
.
Lancet
 
1993
;
341
:
1299
1303
.
15
Lobel
HO
Miani
M
Eng
T
, et al.
Long term malaria prophylaxis with weekly mefloquine
.
Lancet
 
1993
;
341
:
848
851
.
16
Ohrt
C
Richie
TL
Widjaja
H
, et al.
A double-blind, placebo-controlled trial of mefloquine versus doxycycline for the prophylaxis of malaria in Indonesian soldiers
.
Ann Intern Med
 
1997
;
126
:
963
972
.
17
Rieckmann
KH
Yeo
AE
Davis
DR
, et al.
Recent military experience with malaria chemoprophylaxis
.
Med J Aust
 
1993
;
158
:
446
449
.
18
Pergallo
MS
Sabatinelli
G
Majori
G
, et al.
Prevention and morbidity in non-immune subjects; a case-control study among Italian troops in Somalia and Mozambique, 1992–1994
.
Trans R Soc Trop Med Hyg
 
1997
;
91
:
343
346
.
19
Axmann
A
Félegyhazi
CS
Huszar
A
Juhasz
P.
Long term malaria prophylaxis with Lariam in Cambodia, 1993
.
Travel Med Int
 
1994
;
12
:
1
:
13
18
.
20
Hopperus Buma
APCC
van Thiel
PPAM
Lobel
HO
, et al.
Long term malaria chemoprophylaxis with mefloquine in Dutch Marines in Cambodia
.
J Infect Dis
 
1996
;
173
:
1506
1509
.
21
Sanchez
JL
DeFraites
RF
Sharp
TW
Hanson
RK.
Mefloquine or doxycycline prophylaxis in US troops in Somalia
.
Lancet
 
1993
;
341
:
1021
1022
.
22
Wallace
MR
Sharp
TW
Smoak
B
, et al.
Malaria among United States troops in Somalia
.
Am J Med
 
1996
;
100
:
49
55
.
23
Bwire
R
Slootman
EJH
Verhave
JP
, et al.
Malaria anticircumsporozoite antibodies in Dutch soldiers returning from sub-Saharan Africa
.
Trop Med Int Health
 
1998
;
3
:
1
:
66
69
.
24
Muehlberger
N
Jelinek
T
Schlipkoeter
U
, et al.
Effectiveness of chemoprophylaxis and other determinants of malaria in travellers to Kenya
.
Trop Med Int Health
 
1998
;
3
(
5
)
357
363
.
25
Lobel
HO
Varma
JK
Miani
N
, et al.
Monitoring for mefloquine-resistant Plasmodium falciparum in Africa: implications for travelers health
.
Am J Trop Med Hyg
 
1998
;
59
:
129
132
.
26
Magill
AJ
Smoak
BL.
Failure of mefloquine chemoprophylaxis for malaria in Somalia
.
Letter. N Eng J Med
 
1993
;
329
:
16
:
1206
.
27
Wallace
MR
Sharp
TW
Romajzl
PJ
Magill
HO.
Malaria among US troops in Somalia
.
Clin Infect Dis
 
1994
; (
3
)
580
, Abstr 101.
28
Nozais
JP.
Un nouveau cas probable de resistance croisee de Plasmodium falciparum viv-a-vis de la mefloquine et de l'halofantrine, en provenance de Sierre Leone
.
Medecine et Maladies Infectieuses
 
1992
; (
22
) No.
3
,
421
423
.
29
Delmont
J
Faugere
B
Doury
JC
Bourgeade
A.
Paludisme a Plasmodium falciparum consectif a un echec de prophylaxie par mefloquine lors d'un sejour en Cote d'Ivoire
.
Medecine et Maladies Infectieuses.
 
1992
; (
22
) No.
3
,
418
420
.
30
Matteelli
A
Chiodera
A
Castelli
F
, et al.
Failure of mefloquine chemoprophylaxis for malaria in Mozambique
.
J Travel Med
 
1995
;
2
:
260
261
.
31
Kurds
JD
Koros
JK
Duffy
PE
Green
MD.
Malaria prevention for travellers
.
(Letter; comment) JAMA
 
1998
;
278
(
21
):
1767
1771
.
32
Todd
GD
Hopperus Buma
AP
Green
MD
, et al.
Comparasison of whole blood and serum levels of mefloquine and its carboxylic acid metabolite
.
Am J Trop Med Hyg
 
1997
;
57
(
4
):
399
402
.
33
Day
JH
Behrens
RH.
Delay in onset of malaria with mefloquine prophylaxis
.
Lancet
 
1995
;
345
:
398
.
34
Mockenhaupt
FP.
Mefloquine resistance in Plasmodium falciparum
.
Parasitol Today
 
1995
;
11
(
7
)
248
253
.
35
Amor
D
Richards
M.
Mefloquine resistant P. vivax malaria in PNG
.
Med J Aust
 
1992
;
156
(
12
)
883
.
36
Chia
JK
Nakata
MM
Co
S.
Smear-negative cerebral malaria due to mefloquine-resistant Plasmodium falàpamm acquired in the Amazon
.
J Infect Dis
 
1992
;
165
(
3
):
599
600
.
37
Le Bras
J
Durand
R
Di Piazza
JP
Pradines
B
, et al.
Plasmodium falciparum resistance to mefloquine, chloroquine and cycloguanil and prevention of malaria in travelers from France to Africa
.
Presse Med
 
1998
;
27
(
28
):
1419
1423
.
38
Brasseur
P
Kouamouo
J
Moyou-Somo
R
Druilhe
P.
Multidrug resistant falciparum malaria in Cameroon in 1987–1988. II Mefloquine resistance confirmed in vivo and in vitro and its correlation with quinine resistance
.
Am J Trop Med Hyg
 
1992
;
46
:
8
14
.
39
Behrens
RH
Bradley
DJ
Snow
RW
Marsh
K.
Impact of UK malaria prophylaxis policy on imported malaria
.
Lancet
 
1996
; (
9023
):
344
345
.
40
Muentener
P
Schlagenhauf
P
Sceflfen
R.
Imported malaria in industrialized countries. Trends and perspectives
.
Bull World Health Organ
 ; in press.
41
Peters
W.
Drug resistance in malaria parasites of animals and man
.
Adv Parasitol
 
1998
;
41
:
1
58
.
42
White
NJ.
Why is it that antimalarial drug treatments do not always work
Ann Trop Med Parasitol
 
1998
;
92
(
4
)
449
458
.
43
Peel
SA
Bright
P
Yount
B
, et al.
A strong assocation between mefloquine and halofantrine resistance and amplification, overexpression and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro
.
Am J Trop Med Hyg
 
1994
;
51
:
648
658
.
44
Cowman
AF
Galatis
D
Thompson
JK.
Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdrl gene and cross resistance to halofantrine and quinine
.
Proc Nat Acad Sci USA
 
1994
;
91
:
1143
1147
.
45
Oduola
AMJ
Omitowoju
GO
Gerena
L
Kyle
DE
, et al.
Reversal of mefloquine resistance with penfluridol in isolates of Plasmodium falciparum from south-west Nigeria
.
Trans R Soc Trop Med Hyg
 
1993
;
87
:
81
83
.
46
Barrett
PJ
Emmins
PD
Clarke
PD
Bradley
DJ.
Comparison of adverse events associated with the use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers
.
BMJ
 
1996
;
313
:
525
528
.
47
Croft
AMJ
Toxicity of mefloquine is similar to that of other chemoprophylaxis
.
BMJ
 
1995
;
3
:
11
:
191
.
48
Phillips
MA
Kass
RB.
User acceptability patterns for mefloquine and doxycycline malaria chemoprophylaxis
.
J Travel Med
 
1996
;
3
:
40
45
.
49
Jaspers
CA
Hopperus Buma
AP
van Thiel
PP
van Hulst
RA
, et al.
Tolerance of mefloquine prophylaxis in Dutch military personnel
.
Am J Trop Med Hyg
 
1996
;
55
(
2
):
230
234
.
50
Schlagenhauf
P
Steffen
R
Lobel
H.
Johnson
R
, et al.
Mefloquine tolerability during chemoprophylaxis: focus on adverse event assessments, stereochemistry and compliance
.
Trop Med Int Health
 
1996
;
1
(
4
):
485
494
.
51
CIOM International reporting of adverse drug reactions.
CIOMS Working Group Report
Geneva :
World Health Organization
,
1987
.
52
Croft
AJM
World
MJ.
Neuropsychiatric reactions with mefloquine chemoprophylaxis
.
Lancet
 
1996
;
347
:
326
.
53
Croft
A
Garner
P.
Mefloquine to prevent malaria: a systematic review of trials
.
Br Med J
 
1997
;
315
:
1412
1416
.
54
Behrens
RH
Erny
S
Maradit
H
Houston
S
, et al.
Mefloquine to prevent malaria
.
(Multiple letters) Br Med J
 
1998
;
316
:
1980
1981
.
55
Bern
JL
Kerr
L
Stürchler
D.
Mefloquine prophylaxis: an overview of spontaneous reports of severe psychiatric reactions and convulsions
.
J Trop Med Hyg
 
1992
;
95
:
167
179
.
56
Phillips-Howard
PA
ter Kuile
FO.
CNS adverse events associated with antimalarial agents
.
Fact or fiction? Drug Safety
 
1995
;
12
:
370
383
.
57
Wittes
RC
Sagmur
R.
Adverse reactions to mefloquine associated with ethanol ingestion
.
Can Med Assoc J
 
1995
;
152
:
515
517
.
58
Mittelholzer
ML
Wall
M
Steffen
R
Stürchler
D.
Malaria prophylaxis in different age groups
.
J Travel Med
 
1996
;
4
:
219
223
.
59
Jerling
M
Rombo
L
Hellgren
U
Bergqvist
Y
, et al. Evaluation of mefloquine adverse effects in relation to the plasma concentration. Fourth International Conference on Travel Medicine. Acapulco, Mexico, April 23–27, 1995. Abstract No. 95.
60
Hennequin
C
Bouree
P
Bazin
N
, et al.
Severe psychiatric side effects observed during prophylaxis and treatment with mefloquine
.
Arch Interna Med
 
1994
;
20
:
2360
2362
.
61
Clattenburg
RN
Donnelly
CL.
Case study:neuro-psychaitric symptoms associated with the antimalarial agent mefloquine
.
J Am Acad Child Adolesc Psychiatry.
 
1997
;
36
(
11
):
1606
1608
.
62
Lench
P
Bradley
D
Warhurst
D.
Psychological problems after mefloquine and chloroquine
.
BMJ.
 
1995
:
311
:
192
.
63
Carme
B
Nevez
G
Peguet
C
Bouko
I.
Intolerance neuropsychique au sours de la chimiprophylaxis antipalustre par la mefloquine. A propos de 5 observations
.
Bull Epi Herbdomadaire
 
1994
;
34
:
155
.
64
Meszaros
K.
Acute psychosis casused by mefloquine prophylaxis
Can J Psych
 
1996
;
41
:
196
.
65
Hollweg
M
Soyka
M
Greil
W.
Mefloquininduzierte Psychosen—Probleme der Kausalzuordnung anhand zweier kasuistischer Berichte
.
Psychiatrische Praxis
 
1995
;
22
:(
1
)
33
36
.
66
Piening
RB
Young
SA.
Mefloquine induced psychosis
.
Ann Emergency Med
 
1996
;
27
:(
6
)
792
.
67
Grupp
D
Rauber
A
Froescher
W.
Neuropsychiatrische Stoerungen nach Malariaprophylaxe mit Mefloquin
.
Aktuelle Neurologie
 
1994
;
21
(
4
)
134
136
.
68
Marsepoil
T
Petithory
J
Faucher
JM
Ho
P
, et al.
Encephalopathie et troubles amnesiques au cours des traitments par la mefloquine
.
Revue de Medecine Interne
 
1993
;
14
(
8
)
788
791
.
69
Recasens
C
Zittoun
C
Feline
A.
Un episode psychotique au retour dùn voyage en Afrique: implication possible de la mefloquine
.
Annales de Psychiatrie
 
8
: (
2
)
100
103
.
70
Folkerts
H
Kuhs
H.
Psychotische Episode infolge Malariaprophylaxe mit Mefloquine. Eine kasuistische Mitteilung
.
Der Nervenarzt.
 
1992
:
63
(
5
)
300
302
.
71
Caillon
E
Schmitt
L
Moron
P.
Acute depressive symptoms after mefloquine treatment
.
Am J Psychiatry
 
1992
:
149
(
5
)
712
.
72
Ruff
TA
Sherwen
SJ
Donnan
GA.
Seizure associated with mefloquine for malaria prophylaxis
.
Med J Aust
 
1994
;
161
:
453
.
73
Pous
E
Gascon
J
Obach
J
Corachan
M.
Mefloquine-induced grand mal seizure during malaria chemoprophylaxis in a non-epileptic subject
.
Trans R Soc Trop Med Hyg
 
1995
;
89
:
434
.
74
Adamolekun
B.
Epileptogenic potential of antimalarial drugs
.
West Afr J Med
 
1993
;
12
(
4
)
231
232
.
75
Ries
S.
Zerebrale Krampfanfalle während einer Malariaprophylaxe mit Mefloquin
.
Deutsche Medizinische Wochenschrift
 
1993
;
118
:
1911
1912
.
76
Olsen
PE
Kennedy
CA
Morte
PD.
Paresthesias and mefloquine prophylaxis
.
Ann Intern Med
 
1992
;
117
(
12
)
1058
1059
.
77
White
AC
Runnels
JH.
Cutaneous vasculitis associated with mefloquine
.
Ann Intern Med
 
1995
;
123
(
11
)
894
.
78
Martin
GJ
Malone
JL
Ross
EV
Exfoliative dermatitis during malaria prophylaxis with mefloquine
.
CID
 
1993
;
16
(
2
)
341
342
.
79
MacBride
SR
Lawrence
CM
Pape
SA
Reid
CA.
Fatal toxic epidermal necrolysis associated with mefloquine prophylaxis
.
Lancet
 
1997
;
349
:
101
.
80
Nicolas
X
Touze
JE.
La toxicite cardiaque des antipaludiques
.
Medecine Tropicale
 
1994
;
54
(
4
)
361
365
.
81
Richter
J
Burbach
G
Hellgren
U
, et al.
Aberrant atrioventricular conduction triggered by antimalarial prophylaxis with mefloquine
.
Lancet
 
1997
;
349
:
101
102
.
82
Fonteyne
W
Bauwens
A
Jordaens
L.
Atrial flutter with 1:1 conduction after administration of the antmalarial drug mefloquine
.
Clin Cardiol
 
1996
;
19
(
12
)
967
968
.
83
Stracher
AR
Stoeckle
MY
Giordano
MF.
Aplasric anemia during malaria prophylaxis with mefloquine
.
CID
 
1994
;
18
(
2
)
263
264
.
84
Phillips
M.
Antimalarial mefloquine
.
Med J Aust
 
1994
;
161
:
227
228
.
85
Drent
M.
Drug induced pneumonia associated with hemizygote glucose-6-phosphate-dehydrogenase deficiency
.
Eur J Haematol
 
1998
;
61
(
3
)
218
220
.
86
Davis
TME
Dembo
LG
Kaye-Eddie
SA
, et al.
Neurological, cardiovascular and metabolic effects of mefloquine in healthy volunteers: a double-blind, placebo controlled trial
.
Br J Clin Pharmacol
 
1996
;
42
:
415
421
.
87
Hessen-Soederman
AC
Bergenius
J
Berggren
I
Bergqvist
Y
, et al.
Mefloquine prophylaxis, and hearing, postural control and vestibular functions
.
J Travel Med
 
1995
;
2
(
2
)
66
69
.
88
Handschin
JC
Wall
M
Steffen
R
Starchier
D.
Tolerability and effectiveness of malaria chemoprophylaxis with mefloquine or chloroquine with or without co-medication
.
J Travel Med
 
1997
;
4
(
3
)
121
127
.
89
News Lancet
 
1998
;
352
:
1447
.
90
Nosten
F
ter Kuile
F
Maelankiri
L
, et al.
Mefloquine prophylaxis prevents malaria during pregnancy: a double blind, placebo controlled study
.
J Infect Dis
 
1994
;
169
:
595
603
.
91
Steketee
RW
Wirima
JJ
Slutsker
L
, et al.
Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine
.
Am J Trop Med Hyg
 
1996
;
55
:
50
56
.
92
Steketee
RW
Wirima
JJ
Hightower
AW.
Slutsker
L
, et al
The effect of malaria and malaria prevention on offspring birth-weigth, prematurity and intrauterine growth retardation in rural Malawi
.
Am J Trop Med Hyg
 
1996
;
55
(
1
Suppl)
33
41
.
93
Vanhauwere
B
Maradit
H
Kerr
L.
Post-marketing surveillance of prophylactic mefloquine (Lariam) use in pregnancy
.
Am J Trop Med Hyg
 
1998
;
58
(
1
)
17
21
.
94
Phillips-Howard
PA
Wood
D.
The safety of antimalarial drugs in pregnancy
.
Drug Safety
 
1996
;
14
:
131
145
.
95
Balocco
R.
Bonati M. Mefloquine prophylaxis against malaria for female travellers of childbearing age
.
Lancet
 
1992
;
340
:
309
310
.
96
Smoak
BL
Writer
JV
Keep
LW
, et al.
The effects of inadvertant exposure of mefloquine chemoprophylaxis on pregnancy outcomes and infants of US Army service women
.
J Infect Dis
 
1997
;
176
:
831
833
.
This content is only available as a PDF.