1-20 of 33115
Journal Article
Reflections on the Merger of Molecular Endocrinology and Endocrinology
Molecular Endocrinology, Volume 30, Issue 10, 1 October 2016, Pages 1019–1020, https://doi.org/10.1210/me.2016-1128
Published: 03 October 2016
Journal Article
Editorial Reflections on the Demise of Molecular Endocrinology and the Future of Molecular Hormone Action Research
Molecular Endocrinology, Volume 30, Issue 10, 1 October 2016, Pages 1021–1022, https://doi.org/10.1210/me.2016-1131
Published: 03 October 2016
Journal Article
Editorial: Reflections on the Impact of Molecular Endocrinology on a Scientific Career
Molecular Endocrinology, Volume 30, Issue 10, 1 October 2016, Pages 1025–1026, https://doi.org/10.1210/me.2016-1127
Published: 03 October 2016
Journal Article
Origins of the Field of Molecular Endocrinology: A Personal Perspective
Molecular Endocrinology, Volume 30, Issue 10, 1 October 2016, Pages 1015–1018, https://doi.org/10.1210/me.2016-1132
Published: 03 October 2016
Journal Article
Bidding a Fond Farwell to Molecular Endocrinology
Molecular Endocrinology, Volume 30, Issue 10, 1 October 2016, Pages 1023–1024, https://doi.org/10.1210/me.2016-1130
Published: 03 October 2016
Journal Article
Editorial: Final Musings on the Impact of Molecular Endocrinology
Molecular Endocrinology, Volume 30, Issue 10, 1 October 2016, Pages 1027–1028, https://doi.org/10.1210/me.2016-1129
Published: 03 October 2016
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ERK5 nuclear localization is lost in MCF-7 cells that are tamoxifen resista...
in
ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization
Published: 01 October 2016
Figure 1.
ERK5 nuclear localization is lost in MCF-7 cells that are tamoxifen resistant. A, ERK5 (upper panel) and pERK5 (lower panel) immunostaining after 45 minutes of 4-OH-TAM treatment in tamoxifen-sensitive MCF-7 cells and tamoxifen-resistant MCF-7 TAM R cells that were kept in 4-OH-TAM for the indicated
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Derivation of nuclear transport signature and relation to tumor outcome. A,...
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ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization
Published: 01 October 2016
Figure 2.
Derivation of nuclear transport signature and relation to tumor outcome. A, Flow chart presenting derivation of nuclear transport signature. B, List of nuclear transport signature genes and heat map of expression of each gene in different breast cancer subtypes. The root tree shows similarities betw
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XPO1 inhibitor resensitizes tamoxifen-resistant breast cancer cells to tamo...
in
ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization
Published: 01 October 2016
Figure 4.
XPO1 inhibitor resensitizes tamoxifen-resistant breast cancer cells to tamoxifen. A, ERα (+) breast cancer cells are more sensitive to SXR treatment. Dose response for the SXR in ERα (+) MCF-7, T47D, and BT474 cells and ERα (−) MDA-MB-453 and MDA-MB-468 cells. IC 50 values were calculated using a n
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XPO1 is increased in luminal B subtype patient tumor samples and human brea...
in
ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization
Published: 01 October 2016
Figure 5.
XPO1 is increased in luminal B subtype patient tumor samples and human breast cancer cell lines, and increased XPO1 levels increase cell proliferation of tamoxifen-resistant cell lines in the presence of 4-OH-TAM. A, Verification of XPO-1 levels in patient tumor samples. mRNA from tumor FFPE samples
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XPO-1 inhibitor SXR resensitizes BT474 xenograft tumors to treatment with t...
in
ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization
Published: 01 October 2016
Figure 7.
XPO-1 inhibitor SXR resensitizes BT474 xenograft tumors to treatment with tamoxifen. Four- to 6-week-old BALB/C nude mice were ovariectomized and after 1 week were implanted with E2 pellets. The next day the animals were subcutaneously injected with 2.5 × 10 7 BT474 cells in 50% Matrigel. As tumors
Journal Article
Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol
Molecular Endocrinology, Volume 30, Issue 10, 1 October 2016, Pages 1059–1069, https://doi.org/10.1210/me.2016-1023
Published: 01 October 2016
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Disruption of membrane rafts of pancreatic islet cells in type 2 diabetes. ...
in
Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol
Published: 01 October 2016
Figure 1.
Disruption of membrane rafts of pancreatic islet cells in type 2 diabetes. a, Representative images indicating decreased cholesterol in GK rat islets as compared with healthy Wistar rat islets as visualized by filipin fluorescence. b, Mean filipin fluorescence ± SEM (n = 3 in both groups). **, P &
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Increased single Ca2+ channel activity after dispersion of membr...
in
Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol
Published: 01 October 2016
Figure 4.
Increased single Ca 2+ channel activity after dispersion of membrane rafts. a, Effect on charge-voltage (V) relationship of the voltage-dependent currents in control (in gray, n = 22) and CO (in black, n = 21)-treated cells. *, P < .05, **, P < .01, and ***, P < .001, tested by one-w
