Farnesol increases the activity of echinocandins against Candida auris biofilms

Nagy, Fruzsina; Tóth, Zoltán; Daróczi, Lajos; Székely, Adrien; Borman, Andrew M; Majoros, László; Kovács, Renátó

doi:10.1093/mmy/myz057

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Farnesol increases the activity of echinocandins against Candida auris biofilms

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Abstract

Candida auris biofilms exhibit decreased susceptibility to echinocandins, which is associated with poorer clinical outcomes. Farnesol is a quorum-sensing molecule enhancing the activity of antifungals; therefore, we evaluated the in vitro effect of farnesol with anidulafungin, caspofungin, or micafungin against biofilms using fractional inhibitory concentration indexes (FICI), Bliss independence model, LIVE/DEAD-assay and scanning electron microscopy. Based on mathematical models, farnesol caused synergism in eleven out of twelve cases (FICIs range 0.133-0.507; Bliss synergy volume range 70.39–204.6 μM²%). This was confirmed by microscope images of combination-exposed biofilms. Our study showed the prominent effect of farnesol with echinocandins against C. auris biofilms.

Candida auris, biofilm, synergy, farnesol, lock therapy

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Farnesol increases the activity of echinocandins against Candida auris biofilms

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Farnesol increases the activity of echinocandins against Candida auris biofilms

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