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Virtual Issue: Fungal pathogens and Cystic Fibrosis


Cystic fibrosis (CF) is an inherited genetic defect, which stems from a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) and resultant loss of chloride and bicarbonate transport. CF patients have pulmonary, gastrointestinal and pancreatic damage. In the lungs, the defect causes the mucus to become thick and sticky resulting in mucus plugs of the airways. These plugs are difficult to clear and eventually cause obstructive airway disease. In addition, the thick mucus plugs also lead to colonization with a variety of bacteria and fungi, which can progress to infection and further contribute to loss of pulmonary function. The improved treatment and management of CF has led to increased duration of patient survival. The papers in this virtual issue were chosen to highlight the importance of various fungi in their association with CF pulmonary disease.

Karl V. Clemons, PhD
Editor in Chief
Medical Mycology

Chronic Aspergillus fumigatus colonization of the pediatric cystic fibrosis airway is common and may be associated with a more rapid decline in lung function
Rosalind V. Saunders, Deborah E. Modha, Alison Claydon, and Erol A. Gaillard

Aspergillus tubingensis: a major filamentous fungus found in the airways of patients with lung disease
Magali Gautier, Anne-Cécile Normand, Coralie L'Ollivier, Carole Cassagne, et. al

Fungal epidemiology and diversity in cystic fibrosis patients over a 5-year period in a national reference center
S. Ziesing, S. Suerbaum, and  L. Sedlacek

Bronchiectasis and Aspergillus: How are they linked?
Anthony De Soyza and Stefano Alibertihr

Aspergillus fumigatus enhances elastase production in Pseudomonas aeruginosa co-cultures
Karen Smith, Ranjith Rajendran, Stephen Kerr, David F. Lappin, , et. al

Routine processing procedures for isolating filamentous fungi from respiratory sputum samples may underestimate fungal prevalence
Catherine H. Pashley, Abbie Fairs, Joseph P. Morley, Shreeya Tailor, et. al

Clinical associations and prevalence of Scedosporium spp. in Australian cystic fibrosis patients: identification of novel risk factors?
Christopher C. Blyth, Peter G. Middleton, Azian Harun, Tania C. Sorrell, et. al

Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France
André Paugam, Marie-Thérèse Baixench, Nadine Demazes-Dufeu, Pierre-Régis Burgel, et. al

Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis — a review
Marc Pihet, Jacqueline Carrere, Bernard Cimon, Dominique Chabasse, et. al
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