High molecular gas content and star formation rates in local galaxies that host quasars, outflows and jets

We use a sample of powerful z~0.1 type 2 quasars ('obscured'; log[L(AGN)/erg/s]>~45), which host kiloparsec-scale ionized outflows and jets, to identify possible signatures of AGN feedback on the total molecular gas reservoirs of their host galaxies. Specifically, we present Atacama Pathfinder EXperiment (APEX) observations of the CO(2-1) transition for nine sources and the CO(6-5) for a subset of three. We find that the majority of our sample reside in starburst galaxies (average specific star formation rates of 1.7/Gyr), with the seven CO-detected quasars also having large molecular gas reservoirs (average Mgas = 1.3x10^10Msun), even though we had no pre-selection on the star formation or molecular gas properties. Despite the presence of quasars and outflows, we find that the molecular gas fractions (Mgas/Mstar = 0.1-1.2) and depletion times (Mgas/SFR = 0.16-0.95Gyr) are consistent with those expected for the overall galaxy population with matched stellar masses and specific star formation rates. Furthermore, for at least two of the three targets with the required measurements, the CO(6-5)/CO(2-1) emission-line ratios are consistent with star formation dominating the CO excitation over this range of transitions. The targets in our study represent a gas-rich phase of galaxy evolution with simultaneously high levels of star formation and nuclear activity; furthermore, the jets and outflows do not have an immediate appreciable impact on the global molecular gas reservoirs.

vital in both determining the mechanism and impact of feedback (see e.g. Cicone et al. 2018;Cresci & Maiolino 2018). AGN are thought to be able to remove gas from their host galaxies via outflows. These outflows can be powered by the interaction between interstellar gas and small-scale accretion disc winds (Faucher-Giguère & Quataert 2012;Zubovas & King 2012) or directly via radiation pressure on dust (Ishibashi & Fabian 2015;Thompson et al. 2015;Bieri et al. 2017;Costa et al. 2018a,b), particularly for AGN with high Eddington ratios ('quasar' or 'radiative mode'). While typically thought to operate primarily by preventing hot halo gas from cooling, via the so called 'radio' or 'maintenance mode' (e.g. Churazov et al. 2005), collimated jets are also likely to drive outflows of interstellar gas (Wagner et al. 2012;Mukherjee et al. 2016), blurring the division between 'quasar' and 'maintenance' modes (see e.g. Jarvis et al. 2019).
In particular, the potential impact of AGN is most commonly observed through high velocity ionized gas outflows (see e.g. Karouzos et al. 2016;Morganti 2017;Davies et al. 2020). However, if the direct impact of AGN upon star formation is to be understood, it is the cold (∼10 K) molecular gas (primarily composed of H 2 ) which forms the fuel for star formation, that must be considered (Morganti 2017). Since cold molecular gas is not directly observable in H 2 emission, carbon monoxide ( 12 CO which has a permanent dipole moment), is most often used as a tracer of these cold molecular clouds (see e.g. Bolatto et al. 2013;Carilli & Walter 2013, and references therein). Specifically, the ground level transition (J=1-0) has an excitation temperature of just 5.53 K, making it a good tracer of the total cold molecular gas (see e.g. Bolatto et al. 2013), while higher-J CO lines (i.e. J 4-3) are produced from warmer, denser gas (see e.g. Daddi et al. 2015;Mashian et al. 2015;Kamenetzky et al. 2017).
Molecular gas outflows traced by CO gas have been identified in both radio and quasar mode AGN (see e.g. Cicone et al. 2014;King & Pounds 2015;Morganti et al. 2015;Bischetti et al. 2019;Fotopoulou et al. 2019;Oosterloo et al. 2019;Lutz et al. 2020;Veilleux et al. 2020). However these outflows typically only represent ∼10 per cent of the molecular gas luminosity (see e.g. Fluetsch et al. 2019;Lutz et al. 2020) and so are difficult to observe. Instead, the impact of AGN on the molecular gas in their host galaxies is often probed through the total molecular gas content (see e.g. Bertram et al. 2007;Xia et al. 2012;Husemann et al. 2017;Rosario et al. 2018). Specifically, the gas mass and the molecular gas fraction relative to the star formation rate are used to assess the potential impact of the AGN on the star formation efficiency and / or their ability to deplete the molecular gas supply within the host galaxies (e.g. Kakkad et al. 2017;Perna et al. 2018). In addition to removing molecular gas through outflows, AGN and mechanical feedback from jets, can heat the molecular gas, which both inhibits star formation and causes the CO to emit in higher transitions (see e.g. Papadopoulos et al. 2010).
Our recent results, combining integral field spectrographic (IFS) and radio observations, have identified a sample of luminous (L [O III] >10 42 erg s −1 ) type 2 (obscured) AGN with signatures of jets and extended ionized gas outflows. These systems represent the ideal environment to search for signatures of feedback since they have the strong potential to interact with their environments both mechanically and radiatively (Harrison et al. 2014(Harrison et al. , 2015Lansbury et al. 2018;Jarvis et al. 2019). In this work we use unresolved CO measurements of the (2-1) and (6-5) transitions, to investigate the molecular gas content of these systems and look for signatures of the impact of the AGN and jet in particular, through thermal excitation and depletion of the gas reservoir.
In Section 2 we introduce our sample, describe our spectral energy distribution (SED) fitting approach used to determine key galaxy and AGN properties (Section 2.1), and compare our sample to the star forming main sequence (Section 2.2). Section 3 describes our data, data reduction (Section 3.1) and analysis (Section 3.2). In Section 4 we describe our results and in Section 5 we compare the total molecular gas and CO excitation in our systems to literature results (Sections 5.1 and 5.2 respectively) and we discuss these results in the wider context of galaxy evolution in Section 5.3. We present our conclusions in Section 6. We adopt H 0 =70km s −1 Mpc −1 , Ω M =0.3, Ω Λ =0.7 throughout, and assume a Chabrier (2003) initial mass function (IMF).

SAMPLE SELECTION AND PROPERTIES
Here we present observations of the molecular gas in nine type 2 quasars. This sample was designed to be representative of powerful local AGN, with signatures of feedback, and therefore is ideal for identifying the impact of the AGN on the molecular gas reservoir. In particular, by selecting sources with previously identified ionized gas outflows and radio jets, the AGN should be able to impact the molecular gas through radiative and / or mechanical feedback by exciting and / or removing the molecular gas.
In Fig. 1 we show how our targets were selected from the parent sample of 24 264 z < 0.4 spectroscopically identified AGN 1 presented in Mullaney et al. (2013). In Harrison et al. (2014) we selected 16 z < 0.2 type 2 AGN with luminous [O iii] outflows: L [O III] >10 41.7 erg s −1 and full width half maximum (FWHM) 700 km s −1 (see Fig. 1). The only other selection criteria was an ra / dec cut to select sources observable from Gemini-South. Using IFS data we revealed that these outflows are extended on kpc scales. For this work, we selected the nine of these 16 targets with the highest [O iii] luminosities (i.e. L [O III] >10 42 erg s −1 ) and radio luminosities (log[L 1.4GHz /W Hz −1 ]≥23.5; see Fig. 1). In Jarvis et al. (2019) we established that the radio luminosity of these targets is dominated by emission from the AGN, with eight of the nine exhibiting extended radio structures on 1-25 kpc scales, which are likely radio jets (J1010+0612 is the only target without any evidence for an extended radio structure). The spatial coincidence of these radio features to outflows and disturbed ionised gas features visible in the IFS data strongly suggests jet-gas interactions in the majority of this sample (see Harrison et al. 2015;Jarvis et al. 2019

SED fitting
A significant amount of the analysis in this paper relies on having reliable estimates of the star formation rates and stellar masses in our systems without contamination from the AGN. Since the AGN in this work are all type 2, the AGN has only a small contribution to the UV -optical emission but may still contribute significantly to the infrared emission. As such, in Jarvis et al. (2019) we performed UV -IR SED fitting using the 'Code Investigating GALaxy Emission' (CIGALE 2 ; Noll et al. 2009;Buat et al. 2015;Ciesla et al. 2015) to derive the host galaxy and AGN properties of this sample. We used data from GALEX, SDSS, 2MASS, WISE, IRAS, and where available archival, Herschel PACS and SPIRE, for these SED fits, corrected for Galactic extinction (see Jarvis et al. 2019). Specifically, CIGALE simultaneously fits the attenuated stellar emission, star formation heated dust emission, AGN emission (from the accretion disc and dust heating) and nebular emission. Of particular relevance for this work are the stellar mass (M ) and the star formation rate (SFR) of the host galaxies, which are listed in Table 1. We calculated these star formation rates from the SED-derived infrared luminosity due to star formation (L IR,SF ) and the relationship from Kennicutt & Evans (2012), converting from a Kroupa to a Chabrier IMF by multiplying by 0.94 (Madau & Dickinson 2014), specifically: SFR=L IR /(2.57×10 43 )×0.94, with L IR in erg s −1 and SFR in M yr −1 . For further details of the SED fitting, derived quantities and uncertainties we refer the reader to Jarvis et al. (2019).
In Table 1 the quoted uncertainties are 1σ formal errors from the CIGALE fits and do not include systematics. However, there is a 0.3 dex systematic uncertainty expected on the infrared luminosity and stellar mass from the SED fitting (Gruppioni et al. 2008;Mancini et al. 2011;Santini et al. 2015). This results in a 0.42 dex systematic uncertainty for the star formation rate values, from adding in quadrature the systematic uncertainties from the SED fitting and the 0.3 dex systematic uncertainty on the conversion between L IR and SFR (Kennicutt & Evans 2012). Our sources have stellar masses in the range 8×10 9 < M < 1.1×10 11 M and star formation rates in the range 8 < SFR < 84 M yr −1 . All but one of our sources (J1430+1339) are classified as Luminous Infrared Galaxies (LIRGs) based upon their infrared luminosities due to star formation (10 11 -10 12 L ; see Fig. 2).
We verified these values by performing independent SED fits using another code: AGNfitter (Calistro Rivera et al. 2016). The main difference between this code and the CIGALE code is that CIGALE assumes an energy balance between the IR and optical emission for the host galaxy, where AGNfitter considers the two almost independently with a prior that the energy from the IR must be at least equal to the energy attenuated from the stellar emission. For the three of our sources with Herschel observations, which have the best available coverage of the FIR emission (namely J1100+0846, J1356+1026 and J1430+1339; see Jarvis et al. 2019), the IR derived SFRs agree within 0.27 dex (i.e. within the systematic uncertainty). For the remaining six sources the best SFR from AGNfitter is based on the optical emission alone and as such is a lower limit on the actual SFR (Calistro Rivera et al. 2016). In each case this limit is consistent with our SFR from CIGALE. The stellar masses from AGNfitter are on average 0.19 dex higher than those from CIGALE (i.e. within the systematic uncertainty), and the only significant outliers are J1000+1242 and J1010+0612 which have AGNfitter derived stellar masses 0.67 and 0.48 dex larger than those from CIGALE respectively. We note that using the AGNfitter stellar masses and SFRs would not change the main conclusion of this work. In summary, we trust the CIGALE SED-derived stellar masses and SFRs used throughout this work, within the limitations of the unavoidable systematic uncertainties discussed above.

Our targets in the context of the star-forming main sequence
There is a long established trend observed between star formation rate and stellar mass for star-forming galaxies, which is commonly referred to as the "star-forming main sequence" (see e.g. Brinchmann et al. 2004;Daddi et al. 2007;Elbaz et al. 2007;Noeske et al. 2007;Salim et al. 2007;Wyder et al. 2007). This relation provides a useful comparison to put our sample into the wider context of star-forming galaxies. Specifically, we consider where our galaxies lie in comparison to the redshift dependent main sequence of Sargent et al. (2014) (see Fig. 2). We chose this parametrization as it visually provided the best fit to galaxies selected from SDSS (the parent sample of our work); where the other main sequences checked were: Bauermeister et al. We define the distance from the main sequence (∆ MS ) for each source as the ratio of its specific star formation rate (sSFR ≡ SFR/M ) compared to that of the main sequence at its redshift and stellar mass (Sargent et al. 2014). Following the literature, we define our targets as "starbursts" if they have ∆ MS >4 (see e.g. Elbaz et al. 2011); however, we note that we use this definition for a comparison to the overall population only and do not claim that they are physically different to the rest of the population for this work.
Using the definitions described above, all of our sources are on or above their local main sequence with seven classi-3 https://www.sdss.org/dr12/spectro/galaxy_mpajhu/ Our sources compared to the star forming main sequence, as shown by the comparison of stellar mass (M ) and star formation rate (SFR). Our sample is shown as black circles and the APEX CO(6-5) sample is highlighted with blue squares. The red error bar in the top left corner shows the systematic errors (see Section 2.1). The magenta contours and small translucent points show values for star-forming galaxies from SDSS. The solid blue line is the main sequence as given in Sargent et al. (2014) at the mean redshift of our sources (z=0.127), with the width showing the variation across the redshift spanned by our sources. The black dotted line marks the region occupied by starbursts (∆ MS >4) and the black dot-dashed lines marks the limit for LIRGs (L IR ≥10 11 L ). All of our sources lie on or above the main sequence with seven being classified as starbursts.
fied as starbursts 4 , even though we applied no pre-selection on SFR or infrared luminosity (see Table 1).

Data reduction
We use the Atacama Pathfinder EXperiment (APEX) to observe the spatially un-resolved molecular gas emission in the CO(2-1) and CO(6-5) transitions. We observed CO(2-1) for the whole sample presented here and CO(6-5) for a representative sub-sample (J1010+0612, J1100+0846 and J1430+1339; see Figs. 1 and 2). These specific transitions were selected based on a combination of scientific and observational constraints. Specifically, lower CO transitions (CO(1-0) in particular) are best used to trace the total cold molecular gas content (e.g. Bolatto et al. 2013;Carilli & Walter 2013) and the CO(2-1) transition is the lowest observable at the redshift of our targets with the available APEX instrumentation. Higher CO transitions trace molecular gas that has been excited by star formation, shocks and the AGN (e.g. Mashian et al. 2015;Carniani et al. 2019;Vallini et al. 2019). Specifically the CO(6-5) transition was selected based  Abazajian et al. 2009). Additional details of these sources (e.g. radio luminosity and AGN bolometric luminosity) are given in Jarvis et al. (2019). on indications that it can be boosted by AGN activity and jets in particular (Papadopoulos et al. 2010), and because it was the highest transition that could be observed for our targets in a reasonable time using APEX, due to available instrumentation and the atmospheric transmission. Due to observing constraints (e.g. the need for good weather for these observations; see Table 2) we only observed three of our targets in CO(6-5), however these three are representative of the overall population (see Figs. 1 and 2). We observed CO(2-1) for our targets under proposal id. E-0100.B-0166 [PI: Jarvis] with the observations carried out between 2017 July 7 and 2018 December 29 with precipitable water vapours (PWV) between 0.6 and 4.7 mm. Three different instruments were used for these observations due to the redshift range of the targets and changes in the available instrumentation over the period of observation, namely, the Swedish-ESO PI receiver for APEX (SEPIA180; Belitsky et al. 2018), the Max Planck Institute for Radio Astronomy's PI230 and the APEX-1 receiver (SHeFI 230 GHz band; Vassilev et al. 2008). The instrument used for each source, the dates they were observed and the PWV values during the observations are listed in Table 2. The CO(6-5) data was observed under proposal id. E-0104.B-0292 [PI : Harrison] and observed between 2019 August 31 and December 10 using the SEPIA660 band 9 instrument with PWVs between 0.4 and 0.6.
The data were reduced and analysed using the Continuum and Line Analysis Single-dish Software (class; version mar19a). 5 For many of our sources spectral spikes (due to bad channels) were found in at least one polarisation. To correct for this while losing the minimum amount of data for each source, for each day of observations we examined the average spectrum from each of the spectrometers separately and flagged, by eye, any channels affected by spikes. 5 from the GILDAS software package http://www.iram.fr/ IRAMFR/GILDAS/ We also flagged the leading 150 channels (80 for the CO(6-5) data) and trailing 10 (in the overlap region) of each individual spectra. We combined the two spectrometers in the same sideband and polarisation using Zhiyu Zhang's class extension file: combineTwoIFsAPEX.class which is made available online at https://github.com/ZhiyuZhang/gildas_ class_libraries. From each of these combined scans we subtracted a linear baseline using the class base command, excluding a velocity range ∼500 km s −1 to either side of the observed line position or the expected line position from the SDSS redshift if no line was obviously seen in the total binned spectrum. We then removed scans with poor baselines based on the ratio of their rms in 50 km s −1 bins (selected to best reveal the baselines) compared to the theoretical rms (rms t ) calculated by the following equation: where T sys is the system temperature, t is the integration time and dν is the frequency step size. The cutoff value for each was selected based on a combination of visual examination and minimizing the resultant final rms of the combined data in 100 km s −1 bins (selected to best reveal the emission lines) and ranged from rms / rms t =1.25-2. Each day's data were then multiplied by the appropriate Kelvin to Jansky conversion factor. For each time frame and instrument the K/Jy conversion was determined using the APEX telescope efficiencies tool (http://www.apex-telescope.org/ telescope/efficiency/), supplemented by private communications with Juan-Pablo Perez-Beaupuits (see Table 2 for the values used). Finally, the spectra were combined into a single spectrum and re-sampled to 1 km s −1 bins with a final linear baseline removed. We show the final reduced APEX data in the velocity range around the CO(2-1) emission line in Fig. 3 and around the CO(6-5) emission line in Fig. 4. Table 2. Details of the observations Notes: This table is divided into two parts with the details of our APEX CO(2-1) data given first and our CO(6-5) data at the bottom. (1) Object name; (2) Instrument; (3) On source time of the final total spectrum; (4) Date observed (year-month-day); (5) Conversion factor used to convert the observed antenna temperature (in K) to flux density (in Jy); (6) Average precipitable water vapour (PWV; mm) during the observations.  Table 1), and standard deviation (σ; the width of the line) as well as the standard deviation of the noise in the spectrum (σ N ) which we assume to be Gaussian. The results of the fitting are listed in Table 3 and shown in Fig. 3 and 4. The full details of this analysis are given in Appendix A.

Evaluating contamination from other sources and beam corrections
The beams of the APEX observations discussed here are ∼28 arcsec (∼52 kpc at a representative redshift of z = 0.1) for the CO(2-1) data and ∼9 arcsec (∼17 kpc at z=0.1) for the CO(6-5) data. Based on the relatively large beams of the APEX data and considering the optical sizes of our targets we do not expect any CO flux to fall beyond our observed beams, making beam corrections unnecessary. However, the large CO(2-1) beam raises the possibility that other CO bright objects may be contaminating our flux measurements. To check for this scenario, we used higher spatial resolution ALMA CO observations. Specifically, we use the CO(1-0) and CO(3-2) images published in Sun et al. (2014) for J1356+1026 and for the other targets we use preliminary CO(3-2) images from two proposals carried out by our group 7 which have spatial resolution of ∼0.3-0.5 arcsec and a maximum recoverable scale of ∼4 arcsec. 8 The only target where a possible contaminating CO source was identified is J1010+0612 which has a CO(3-2) bright companion ∼7 arcsec away, which is within our CO(2-1) beam. Preliminary flux measurements from the ALMA data reveal that ∼82 per cent of the total flux is in our primary target of J1010+0612, a difference which is within the 1σ error bars from our Bayesian fit. 9 We highlight this source in subsequent figures.

RESULTS
We show the final reduced APEX data, in 100 km s −1 bins, around the CO(2-1) line (for all nine targets) in Fig. 3 and around the CO(6-5) line in Fig. 4 (for the three targets observed). In the online supplementary data for this paper we provide corner plots displaying the posterior probability distributions of each of the parameters for each source. For the CO(2-1) data all but J0958+1439 and J1356+1026 show distinct peaks in the probability distribution for each parameter, indicating a detection. Therefore we detect seven of our nine targets in CO(2-1). None of the three sources observed in CO(6-5) show distinct peaks in the posterior probability distributions of all parameters and are clearly undetected. Obs. F equency (GHz) Figure 3. Our APEX CO(2-1) data (black curve) for each source. Over plotted for each is the results of our Bayesian fitting to the emission line, specifically the Gaussian constructed from the 50th percentile value from the posteriors for each parameter (magenta; see Table 3). For the two non detections a black horizontal line at flux=0 is plotted to help guide the eye. For the detected emission lines we quote the 50th percentile (median) of the posterior distribution for each parameter in Table 3, and use the 16th and 84th percentile as errors. We note there is an additional ∼13 percent systematic uncertainty on the line flux from the error on the temperature to flux density conversion factors (Section 3.1). The values derived from our Bayesian analysis are consistent within errors to those derived from fitting a Gaussian directly to the data in 100 km s −1 bins. In Fig. 3 we show the resulting line profiles from our Bayesian procedure as Gaussians constructed using the 50th percentile value for each parameter. These parameter values will be adopted for the analyses throughout this work.
For the non-detected emission lines we derived 3σ upper limits on the line flux from the 99.7th percentile on the posterior distribution (see values in Table 3). Our upper limit for J1356+1026 (i.e. L CO (2−1) <6×10 9 K km s −1 pc 2 ) is consistent with the observed value obtained by converting the total L CO (1-0) reported for this source in Sun et al. (2014) to CO(2-1) (i.e. L CO (2-1)=0.82×10 9 K km s −1 pc 2 ), where we have assumed L CO (2-1)/(1-0)≡r 21 =0.8 (see Section 5.1.2 for a discussion of the choice of r 21 ). J1356+1026 is discussed in more detail in Section 5.1 and Section 5.3.  2014) for main sequence and starburst galaxies, respectively (see Section 5.1.1). Our quasars appear to follow the trend of star-forming galaxies, with those further from the main sequence agreeing more closely with starburst relation. J1010+0612 is highlighted with a red outline because the L CO may be 18 per cent overestimated (see Section 3.2).
We have no prior knowledge of the total CO emission for J0958+1439.
Overall we detect the CO(2-1) line for seven of our nine targets with fluxes in the range 7-23 Jy km s −1 . The two non detected targets have upper limits of 21.5 and 33.1 Jy km s −1 (for J0958+1439 and J1356+1026, respectively). Our upper limits on the CO(6-5) fluxes are 110, 74 and 135 Jy km s −1 for J1010+0612, J1100+0846 and J1430+1339, respectively. For the CO(2-1) detections we measured peak line velocities between −320 and 50 km s −1 relative to the systematic redshifts in Table 1, and line widths (σ) between 150 and 200 km s −1 ; however, we defer a discussion of the molecular gas kinematics to future work.
We calculate the CO luminosities (following e.g. Solomon et al. 1997) for each source using: where D L is the luminosity distance in Mpc, ν co,rest is the rest-frame frequency of the CO line in GHz (230.538 and 691.473 GHz for the CO(2-1) and CO(6-5) lines respectively), and f is the flux of the CO line in Jy km s −1 . This results in L CO (2-1) values of (1.4-7)×10 9 K km s −1 pc 2 for the seven detected sources (see Table 3). These are plotted as a function of infrared luminosity in Fig. 5 and are discussed in the following section.

DISCUSSION
In this work we look for signatures of AGN feedback on the molecular gas in our quasar sample. They are luminous AGN with ionized outflows and jets which may be able to impact upon the gas supply either radiatively or mechanically (see e.g. Harrison 2017, for a review). We stress that although molecular outflows are commonly observed directly through broad, generally blue shifted emission line components (see e.g. Fluetsch et al. 2019;Lutz et al. 2020); they are typically weak in CO emission (contributing 10 per cent of the total emission-line profile), which would be undetectable in our data. Here we focus on the galaxy-wide molecular gas content (Section 5.1) and CO excitation (Section 5.2) of our sample of extreme quasars and compare them to redshiftmatched literature galaxy samples both with and without AGN.

Molecular gas content
In order to assess if our AGN have depleted their host galaxies' gas reservoir or decreased their star formation efficiency, we compare our results to studies of general galaxy populations and other AGN samples. Specifically, we consider: (1) their total CO luminosities (L CO ) compared to their infrared luminosities (L IR ; corrected for the AGN contribution; Section 5.1.1); (2) how the molecular gas fractions (M gas /M ) and depletion times (M gas /SFR) compare to other samples when star-formation rates, stellar masses and offsets from the star-forming main sequence (∆ MS ) are taken into account (section 5.1.2) and (3) the relationship between AGN properties and the molecular gas content and star formation of the host galaxy (Section 5.1.3).

L CO / L IR relations
The correlation of L CO (which traces the molecular gas mass) and L IR (which traces star formation) in star-forming galaxies is well studied (e.g. Kennicutt 1998;Genzel et al. 2010;Greve et al. 2014;Sargent et al. 2014). By directly comparing observable quantities, this analysis removes many of the assumptions that are needed to convert these values into physical parameters. A complication to this analysis, which is not always accounted for, is that AGN can contribute significantly to the IR emission (see e.g. Kirkpatrick et al. 2019). The careful SED fitting technique implemented in our work allows us to reliably consider only the IR luminosity from the star formation component which is free from AGN contamination (i.e. L IR,SF ; see Section 2.1). Numerous works have parametrized the L CO -L IR relation using different samples of galaxies and different CO transitions. Here we focus on the work of Sargent et al.  Table 3. CO emission-line measurements Notes: This table is divided into two parts with the details of our fits to the APEX CO(2-1) data given first then our fits to the CO(6-5) data are in the bottom portion. (1) Object name; (2-5) are values derived from our Bayesian fits to the APEX data, consisting of the 50th percentile (median) value with errors derived from the 16th and 84th percentiles: (2) line flux in Jy. For non-detections 3σ upper limits are given; (3) Peak velocity in km s −1 with respect to the systematic redshift given in Table 1; (4) Width of the line as a standard deviation in km s −1 ; (5) Standard deviation of the noise in the final 1 km s −1 binned spectrum (see Section 3.2); (6) L CO / 10 9 in K km s −1 pc 2 . † Due to a nearby CO bright companion which is included within the CO(2-1) beam, the true CO(2-1) flux of this source could be up to 18 per cent lower than the value given here (see Section 3.3; the other line parameters are not used in the discussion of this paper). . We compare the L CO and L IR values for the nine targets in our sample to this relation in Fig. 5. We find that two out of the seven CO(2-1) detected quasars are consistent with the L CO -L IR relationship for main sequence star-forming galaxies, whilst the other five have L CO values up to a factor of ∼4 lower than the relation would predict for their L IR (see Fig. 5). However, as highlighted by the colour scaling in Fig. 5, all of the targets with low L CO compared to the Sargent et al. (2014) main sequence relationship have high star formation rates in relation to the main sequence (i.e. they have high ∆ MS values; see Section 2.2). This is consistent with Sargent et al. (2014), which finds that starbursts are offset to lower L CO values by a factor of ∼2.9, on average, compared to main sequence galaxies (see dotted line in Fig. 5). Indeed, all of our quasars which fall below the L CO -L IR relationship for main sequence galaxies are classified as starbursts (i.e. ∆ MS 4) and fall within 0.3 dex of the Sargent et al. (2014) relationship for starburst galaxies. We note that similar results are found when comparing our sample to the LIRG and merger L CO -L IR relationships of Greve et al. (2014) and Genzel et al. (2010), respectively.
Based on our data, the two CO(2-1) non-detected targets could still be consistent with the expected relationships for star-forming galaxies (the main sequence and star- burst relations for J0958+1439 and J1356+1026, respectively); but could also lie significantly lower. Specifically, we note that using the Sun et al. (2014) CO(1-0) luminosity for J1356+1026 would place it ∼4 times lower than the Sargent et al. (2014) starburst relation (see Fig. 5). This source is discussed in more detail in Section 5.1.2 and Section 5.3.
In summary, we find that at least seven of our nine targets have L CO values consistent with those of the starforming galaxy population at matched infrared luminosities and at similar distance to the main sequence. From this analyses there is no evidence that the observed ionized outflows and jets in our powerful quasars have had an instantaneous impact on the observed CO luminosities.

Molecular gas comparisons
The more physically motivated quantities to study are the gas fraction (ratio of the molecular gas mass to stellar mass) and the depletion time (ratio of the molecular gas mass to the star formation rate), which relates to how efficiently stars are being formed for a given molecular gas mass. Based on large galaxy samples, these molecular gas properties scale with redshift, stellar mass and distance from the star-forming galaxy main sequence (see e.g. Tacconi et al. 2018;Liu et al. 2019, and references therein). In this work we are not concerned with the physical significance of these relations, but use them as a tool to compare the molecular gas properties of our sample to the wider galaxy population.
We compare our data to the homogenised sample of Tacconi et al. (2018) limited to within ±0.05 of the maximum and minimum redshift of our sample and only using their CO based measurements. 11 Specifically, the data compiled comes from the xCOLD GASS (Saintonge et al. 2017), EG-NOG (Bauermeister et al. 2013) and GOALS (Armus et al. 2009) surveys and from the sample presented in Combes et al. (2011). We identified AGN hosts for each sample using BPT-based AGN classifications (the same as used to identify our sample; see Section 2), where available, and including all AGN classes (e.g. LINERS, Seyferts, quasars, composite; Baldwin et al. 1981). The galaxies in this redshift-matched comparison sample span the complete range of stellar mass, sSFR and ∆ MS found for our sample (see Fig. 6).
To ensure consistency with the comparison sample, we calculate the molecular gas masses of our samples using the same procedure as in Tacconi et al. (2018). Specifically, we follow the metallicity dependent α CO and mass-metallicity relation used by Tacconi et al. (2018) (see also Genzel et al. 2015) to calculate molecular gas masses following M gas = α CO ×L CO (1-0). The resultant α CO values for our sample range from 4.0 to 4.2. We convert from L CO (2-1) to L CO (1-0) using r 21 =0.8. The full details of the equations used and a table of derived values are presented in Appendix B. For our seven CO(2-1) detected targets, the derived molecular gas masses fall in the range of 9.9<log(M gas /M )<10.5, with corresponding ranges of gas fractions and depletion times of M gas /M =0.1-1.2 and M gas /SFR=0.16-0.95 Gyr, respectively.
In Fig. 6 we compare our derived gas masses and depletion times to the Tacconi et al. (2018) population as a function of stellar mass, sSFR and ∆ MS . We note that the dependence on the choice of main sequence relation adds additional uncertainty to ∆ MS compared to sSFR; however, ∆ MS has been shown to be more closely related to the molecular gas properties (see e.g. Tacconi et al. 2018;Liu et al. 2019) and we obtain consistent conclusions if we just consider sSFR. Within errors, our sources overlap with the comparison sample (non-AGN and AGN) in all of the common diagnostic planes shown in Fig. 6. To quantify this comparison, we perform a simple log linear fit to the Tacconi et al. (2018) sample with AGN removed (see Fig. 6). Our sample have a median log vertical offset of +0.1 in the gas fraction versus ∆ MS plane and +0.04 in the depletion time versus ∆ MS plane (ignoring the non-detections). 12 This provides some evidence for moderately high (∼0.1 dex) gas fractions in our sample, with respect to their position relative to the main sequence. However, we can not rule out that the two non detected sources in our sample could bring our average down. Specifically, calculating the gas mass for J1356+1026 using the total L CO (1-0) from Sun et al. (2014)  The AGN included in Tacconi et al. (2018), which have no selection for high bolometric luminosity or outflows, go in the opposite direction to our CO-detected targets, with median log vertical offsets of −0.12 in the gas fraction versus ∆ MS plane and −0.07 in the depletion time versus ∆ MS plane. We explore the possible role of AGN power further in Section 5.1.3. It is important to consider possible systematic uncertainties in comparing AGN to non AGN samples due to the assumptions required to calculate gas masses. 13 For example, there is no consensus on if AGN have systematically different ratios of L CO (2-1) and (1-0), which is used to convert between the two (r 21 ; see e.g. Ocaña Flaquer et al. 2010;Papadopoulos et al. 2012;Xia et al. 2012;Husemann et al. 2017;Shangguan et al. 2019); however, we note that the observed range is modest (0.4<r 21 <1.2) and we have adopted the mean value of 0.8 throughout this work (see e.g. Braine et al. 1993;Leroy et al. 2009). A larger uncertainty comes from α CO , which, for most galaxies appears to have a value of ∼4, with slight dependencies on metallicity and SFR (see e.g. Bolatto et al. 2013;Sandstrom et al. 2013, and references therein). However α CO may be significantly lower in LIRGs, submillimetre galaxies, mergers, starbursts and AGN (as low as ∼0.6; see e.g. Bolatto et al. 2013;Sargent et al. 2014;Calistro Rivera et al. 2018). In our comparison to literature results we have controlled for many of these differences, i.e. we are comparing like-for-like in sSFR and ∆ MS and made consistent assumptions (see Appendix B). However, we can not rule out some level of systematic differences in α CO for AGN which could shift our sources to systematically lower gas masses than the non-AGN comparison sample. Finally, we note that a limitation of our comparison to the Tacconi et al. (2018) catalogue is that it does not provide information on detection fractions or report upper limits. However, if anything, this limitation will strengthen our suggestion that the majority of the quasars in our sample, are comparatively gas rich.
To summarize, although we can not control for unknown systematic variations in α CO , our quasar sample has molecular gas fractions and depletion times that are consistent with, or slightly higher than, the redshift matched comparison sample when considered in terms of their stellar masses, sSFRs or distances to the main sequence. This implies no significant rapid depletion of the molecular gas supply despite the presence of kpc ionized gas outflows and jets.

The impact of AGN on the molecular gas content
To investigate the relationship between AGN and the molecular gas content in more detail, we build upon the work of Saintonge et al. (2017) which found that the BPT selected AGN in the xCOLD GASS sample with the highest [O iii] / Hβ ratios (taken as a proxy of the power of the AGN radiation field) tend towards higher gas fractions. In Fig. 7 we plot gas fractions as a function of the [O iii] / Hβ ratio for both the xCOLD GASS sample and the quasars presented in this work. For a fair comparison with the Saintonge et al. (2017) data we, again, use r 21 =0.8, and follow their method to obtain α CO . That is, we use the metallicity Quasars from this work: +0.11 Tacconi+18 AGN: -0.12 APEX CO(2-1) data J1356+1026; Sun+14 0.04<z<0.25 non-AGN (Tacconi+18) Tacconi+18 AGN APEX CO(2-1) data J1356+1026; Sun+14 0.04<z<0.25 non-AGN (Tacconi+18) Tacconi+18 AGN 10 1 10 0 10 1 10 2

MS
Tacconi+18 AGN: -0.07  2018), within z ±0.05 of the full range of redshifts spanned by our sample. Galaxies without an identified AGN are represented by green points and density contours and AGN host galaxies by magenta squares (see Section 5.1.2). We show how the molecular gas fractions (M gas /M ; top row) and depletion times (M gas /SFR; bottom) vary with: stellar mass (M ; left column), sSFR (middle column) and distance to the main sequence (∆ MS ; right column; see Sect. 2). J1010+0612 is highlighted with a red circle following Fig. 5 and a black diamond in each panel marks the value for J1356+1026 using L CO (1-0) from Sun et al. (2014) instead of the limit from this work. In each panel a representative error bar is shown which factors in the systematic errors that could cause relative shifts between this work and the comparison sample (i.e. the conversion from L IR to SFR and the error on the K/Jy conversion from APEX; see Sections 2.1 and 4). In the ∆ MS column (right) the median log vertical distance from a linear fit to the Tacconi et al. (2018) non-AGN (green dashed line) is given. Our powerful CO detected quasars, containing both outflows and jets, follow the overall trends seen in the comparison sample in all panels.
and ∆ MS dependent function of Accurso et al. (2017), which results in α CO values between 3.3 and 6.0, and gas masses of 9.8<log(M gas /M )<10.5 (for the seven detected targets; see Appendix B for full details). 14 Fig. 7 reveals that our sample, extending to the most extreme local AGN, with no pre-selection on molecular gas or star forming properties, agrees with and strengthens the previous results from xCOLD GASS: the more extreme AGN   Fig. 6). We note however, that our sample covers a very narrow range of [O iii] / Hβ and xCOLD GAS is not designed as an AGN survey and so due to volume and redshift limits does not contain any powerful AGN. Larger samples, uniformly covering AGN with a range of powers would be needed to strengthen this observation. We discuss the impact of these results on the relationships between AGN activity, molecular gas masses and star formation rates in Section 5.3.

CO excitation
The relative luminosity of different CO lines contains information about the conditions of the molecular gas and the mechanisms that are exciting it. Through our APEX observations we put constraints on the ratio of the CO(6-5) to the CO(2-1) luminosity (L CO ; r 62 ) for three sources in our sample. Specifically, we find r 62 <0.66, 0.35 and 0.89 for J1010+0612, J1100+0846 and J1430+1339 respectively (see  Kamenetzky et al. (2016). For at least two of our sources (J1010+0612 and J1100+0846) we do not have any evidence for highly excited CO SLEDs (see Sec. 5.2).
close companion, the limit on r 62 increases marginally to 0.8 (which is within the error bar shown in Fig. 8).
The most ubiquitous source of CO excitation is photodissociation regions (PDRs) from the UV photons emitted from young stars. However this mechanism is inefficient at exciting higher CO transitions. Shocks and / or X-ray emission (through X-ray-Dominated Region models; XDR), both of which can be powered by AGN or jets, are needed to further excite the CO gas (see e.g. Pereira-Santaella et al. 2013;Carniani et al. 2019).
The CO spectral line energy distribution (SLED) modelled by Narayanan & Krumholz (2014), which depends solely on the star formation rate surface density (Σ SFR ), predict values of r 62 0.24 for typical star formation rate surface densities of 10 M yr −1 kpc −2 , and even for an exceptionally high limit of Σ SFR =1000 M yr −1 kpc −2 , r 62 0.6 can not be achieved. Our observed limit for J1100+0846 in particular suggests that the excitation of its total molecular gas could be explained by star formation alone, even at the highest end of the possible r 62 ratio for this source. For J1010+0612 the observed limit of r 62 <0.66 could be explained by star formation alone; however, some contribution of shocks and XDR, possibly powered by the AGN can not be ruled out.
In Fig. 8 we also show the distribution of observed r 62 ratios from Kamenetzky et al. (2016) and Papadopoulos et al. (2012). This shows that the majority of sources are consistent with their CO(6-5) emission being caused by PDR. However, for the galaxies with r 62 0.24, it is worth noting that their relatively excited state would re-quire either fairly high star formation rate surface densities (>10 M yr −1 kpc −2 ) or imply the presence of another excitation mechanism (i.e. shocks or XDR). The three most extreme sources in these samples (r 62 0.6; IRAS 08572+3915 at 1.1, NGC 34 at 0.92 and 3C 293 at 0.78) all have a strong indication that AGN activity is responsible for the abnormally high r 62 (see e.g. Cicone et al. 2014;Mingozzi et al. 2018;Emonts et al. 2005;Floyd et al. 2006;Papadopoulos et al. 2010). Our observed r 62 limits on J1010+0612 and J1100+0846 can rule out such an extreme AGN excitation as seen in these sources. Unfortunately our weaker limit on J1430+1339, which of the three targets observed in CO(6-5) shows the clearest indications of jet activity (Jarvis et al. 2019), does not allow us to place any constraints on the excitation source for the CO(6-5) emission.
In summary, despite the fact that our targets containing kpc-scale ionized outflows ( Fig. 1; Harrison et al. 2014;Jarvis et al. 2019), we see no evidence that the CO emission is extremely excited based on the L CO (6-5)/CO(2-1) ratios. This result is not entirely unexpected. For example, Rosenberg et al. (2015) found that the infrared colours of galaxies is a strong predictor of their CO excitation. Based on this, our galaxies (with IRAS 60/100µm flux 1) should not have highly excited CO. Also, the effect of the AGN is expected to be most clearly seen at J>10 (e.g. Mashian et al. 2015;Lu et al. 2017) or at extreme gas densities (e.g. Lamperti et al. 2020). Observations of higher CO transitions could provide a more complete constraint on the influence of the AGN (see e.g. Mashian et al. 2015;Carniani et al. 2019) and spatially resolved observations at multiple CO transitions would enable a study of any localised impact on the gas by the AGN or jets which could be undetectable in the total galaxy-wide emission (see e.g. Dasyra et al. 2016;Zhang et al. 2019).

The role of AGN in galaxy evolution
Many works have explored the total molecular gas content of AGN host galaxies compared to non-AGN galaxies (e.g. Simpson et al. 2012;Husemann et al. 2017;Kakkad et al. 2017;Perna et al. 2018;Rosario et al. 2018;Shangguan et al. 2019;Kirkpatrick et al. 2019); however, due to the huge amount of variation in the data used, the analysis conducted and the different selection criteria for comparison samples, creating a unified picture of these results is challenging. The most consistent conclusion seems to be that the molecular gas content for low-redshift (z 1) AGN populations, is broadly consistent with matched non-AGN galaxies (see e.g. Xia et al. 2012;Krips et al. 2012;Villar-Martín et al. 2013). 15 Our comparison to non-AGN samples generally supports these broad conclusions: we find, at most, moderate differences in observed or derived molecular gas properties for our quasar sample compared to galaxy samples matched in redshift, stellar mass, sSFR and ∆ MS (see Fig. 5 and Fig. 6). Additionally, our results suggest that powerful type 2 AGN with signatures of ionized gas outflows and jets, reside preferentially in gas rich, starburst galaxies.
In Sections 5.1 and 5.2 we showed that in our sample of local quasars with kpc ionized gas outflows and jets, there is no indication of AGN feedback having an immediate impact on the total gas reservoir once their distance to the star forming main sequence is accounted for. These observations; however, are unable to rule out a more localised impact, which can sometimes be observed using spatially-resolved molecular gas measurements (e.g. Salomé et al. 2017;Rosario et al. 2018;Fotopoulou et al. 2019;Ramakrishnan et al. 2019;Shin et al. 2019;Lutz et al. 2020). Furthermore, we can not rule out that these processes will have an impact on the global molecular gas supply on longer timescales. Specific predictions of the typical spatial scales and time frames of the impact on the molecular gas reservoirs are required to test different AGN feedback models (see e.g. Lapi et al. 2014), which has already started to be investigated on host galaxy star formation rates (see e.g. Harrison 2017;Scholtz et al. 2018;Schulze et al. 2019).
Figures 6 and 7 indicate that our quasars lie preferentially in molecular gas rich systems even though our only pre-selections were on the width and luminosity of [O iii] and radio luminosity. Indeed, these systems are more gas rich, and are more likely to reside in starburst galaxies, than less extreme AGN host galaxies (Fig. 7). This is also in qualitative agreement with recent work revealing a relationship between AGN power and offset from the main sequence (at least at z ∼1; Bernhard et al. 2019;Grimmett et al. 2020). Although indirectly, our work is consistent with a link between AGN activity and star formation that is driven by the underlying gas content of the host galaxy. Furthermore, similar results have been found in works considering atomic gas and high redshift sources (see e.g. Ellison et al. 2019;Rodighiero et al. 2019, respectively).
It is worth noting that one of our sources, which is undetected in our APEX data, may be exceptional in that it does have a low gas content. Using the Sun et al. (2014) CO(1-0) luminosity of L CO =1.03×10 9 K km s −1 pc 2 for J1356+1026 would put it amongst the most gas poor sources in our comparison sample from Tacconi et al. (2018) (M gas /SFR=0.05 Gyr) and cause it to fall ∼4 times lower than the Sargent et al. (2014) starburst relation (see Fig. 5). This implies either that the luminosity reported in Sun et al. (2014) does not detect all of the diffuse, low surface brightness CO emission, or could imply that this source is more rapidly quenched than the rest of our sample. The most obvious exceptional property of this source, which could impact its molecular gas content compared to the rest of the sample, is the double nuclei separated by ∼2.5 kpc (Greene et al. 2012), indicating an on-going merger.
Overall the observed high molecular gas masses and incidence of starbursts in our sample are consistent with the scenario where the AGN and star formation are linked, and is in broad agreement with simple evolutionary based AGN unification models (see e.g. Sanders et al. 1988;Hopkins et al. 2006;Hickox et al. 2009). Specifically, the well studied scenario where gas rich systems have high levels of star formation and obscured / type 2 AGN activity (possibly triggered by mergers) which is followed by feedback processes (such as outflows and jets) that will ultimately quench the AGN activity and star formation in the galaxy. Larger, less biased samples would be needed to confirm these models however. Although we can not be sure of the fate of our galaxies, we may have caught these systems in a special evolutionary phase where the feedback processes are just beginning. We can concretely conclude that the outflows and jets we observe do not rapidly remove the global molecular gas in an appreciable way (i.e. on a timescale shorter than, or equal to, the observed quasars, jets or outflows).
Our findings are consistent with many previous studies of the molecular gas and star formation in low redshift AGN (z 0.2). For example, Husemann et al. (2017) find gradually increasing amounts of molecular gas going from AGN in bulge dominated to disc dominated to major merger host galaxies and a trend to higher molecular gas masses in systems with more luminous AGN. Similarly, Bertram et al. (2007) find that the Seyferts in their sample have molecular gas content consistent with normal star forming galaxies, while the powerful quasars are more consistent with starbursts. Luminous AGN are known to generally reside in galaxies with more recent star formation than their lower luminosity counterparts (see e.g. Balmaverde et al. 2016;Bernhard et al. 2019;Grimmett et al. 2020;Kim et al. 2020). Finally, there is evidence that obscured AGN lie in more gas rich systems than their un-obscured counterparts (Wylezalek & Zakamska 2016; Rosario et al. 2018) and that the most extreme outflows may be preferentially found in rapidly starforming, gas rich systems (see e.g. Rodríguez Zaurín et al. 2013;Harrison et al. 2014;Wylezalek & Zakamska 2016).
To summarize, we find that our sample, selected to be luminous type 2 AGN hosting ionized outflows, lie preferentially in gas rich galaxies, with high levels of simultaneous star formation, which is consistent with the evolutionary framework described above. However, the small size of this sample and the two non-detections limit our ability to expand these findings to the quasar population in general. By selecting systems with fast, prominent kpc ionized gas outflows we might have expected these outflows to be able to remove the molecular gas, resulting in a deficit. However, the data suggest that if these outflows or jets will ultimately have an impact on the global molecular gas content, it is subtle, or we have captured them too early in the feedback process for this effect to be measurable.

CONCLUSIONS
Using APEX observations of the CO(2-1) emission line we have explored the global molecular gas content of nine z ∼ 0.1 galaxies selected to host powerful type 2 quasars (log[L AGN /erg s −1 ] 45) with galaxy-wide ionized outflows and radio jets (see Fig. 1; Harrison et al. 2014;Jarvis et al. 2019). We detected seven of the nine targets in CO(2-1), with corresponding L CO (2-1) values of (1.4-7)×10 9 K km s −1 pc 2 . For a subset of three targets we used APEX to obtain upper limits on the CO(6-5)/CO(2-1) emission-line ratios. Our main conclusions are: (i) For at least seven of the nine quasars in our sample, the total molecular gas reservoirs show no indication of being rapidly depleted due to AGN feedback, despite being selected to have powerful ionized gas outflows and jets. Firstly, we find CO luminosities consistent (within 0.3 dex) with what would be predicted for the general galaxy population given their L IR and distance to the star-forming main se-quence (see Fig. 5 and Section 5.1.1). Secondly, the derived gas fractions and depletion times of our seven CO(2-1) detected sources (i.e. M gas /M ≈0.1-1.2 and M gas /SFR≈0.16-0.95 Gyr, respectively) are comparable to those of redshiftmatched non-AGN star-forming galaxies when taking into account their stellar mass, specific star formation rate and distance from the main sequence (see Fig. 6 and Section 5.1.2).
(ii) Galaxies hosting powerful AGN (i.e. log([O iii]/Hβ) 0.6) tend to have systematically higher gas fractions than those with less powerful AGN and starforming galaxies in general, when our sample is considered together with those from the xCOLD GASS survey (Saintonge et al. 2017). Galaxies across these samples with the highest gas fractions appear to contain the most powerful AGN and highest levels of concurrent star formation (in relation to the star-forming main sequence; see Fig. 7 and Section 5.1.3).
(iii) The AGN are not having an extreme impact on the global CO excitation in at least two of the three sources for which we have upper limits on the L CO (2-1)/CO(6-5) emission-line ratios (i.e. r 62 0.66; see Fig. 8 and Section 5.2).
In summary, we find that the majority of our sample of quasars have gas rich, starburst host galaxies, even though we did not select the sample based on these properties. Furthermore, we find that their gas masses are consistent with what would be expected for their observed levels of star formation. There are no signs of an instantaneous depletion of the total molecular gas reservoir by the AGN in our sample, despite their high bolometric luminosities, strong ionized gas outflows and the presence of kpc scale jets in many. Our results are consistent with a requirement for high molecular gas fractions to feed both quasar activity and intense periods of star formation. Indeed, by selecting luminous AGN with powerful ionized gas outflows, we may have predominantly selected galaxies in a phase in their evolution where intense star formation and AGN activity are powered by large molecular gas reservoirs and the "feedback" in the form of jets and outflows is relatively young and these processes have not yet had any global impact upon the host galaxies.
Future, higher resolution CO observations and observations of more CO transitions will help determine if these processes have a more subtle and / or localised impact upon the molecular gas properties. Furthermore, galaxy formation models should work towards specific predictions of the molecular gas properties (e.g. gas fractions, depletion times, excitation) to compare to observations, such as ours, to aid understanding of the expected physical scales and time frames of any impact caused by different AGN feedback model prescriptions.

DATA AVAILABILITY STATEMENT
The data underlying this article were accessed from the ESO Science Archive Facility: http://archive.eso.org/eso/ eso_archive_main.html under programme IDs E-0100.B-0166 and E-0104.B-0292. The derived data generated in this research will be shared on reasonable request to the corresponding author.